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Transgenic expression of the proneural transcription factor Ascl1 in Müller glia stimulates retinal regeneration in young mice

2015; National Academy of Sciences; Volume: 112; Issue: 44 Linguagem: Inglês

10.1073/pnas.1510595112

1091-6490

Yumi Ueki, Matthew S. Wilken, Kristin E. Cox, Laura B. Chipman, Nikolas L. Jorstad, Kristen Sternhagen, Milesa Simic, Kristy Ullom, Masato Nakafuku, Thomas A. Reh,

Zebrafish Biomedical Research Applications

Significance The retina is subject to a variety of insults that lead to degeneration of one or more types of neurons and ultimate visual impairment and blindness. Although the retinas of nonmammalian vertebrates can regenerate new neurons after injury, mammalian retinas largely lack this potential. We have tested whether the expression of the proneural transcription factor Ascl1 may be a key difference between the fish and mouse by targeting this factor to the cells that provide new retinal progenitors in mature retina, the Müller glia. Our results show that at least one of the differences between mammal and fish Müller glia that bears on their difference in regenerative potential is the proneural transcription factor Ascl1.