Potential Gastrointestinal injury by ion-exchange resins
2015; Elsevier BV; Volume: 37; Issue: 8 Linguagem: Inglês
10.1016/j.clinthera.2015.05.338
ISSN1879-114X
AutoresM.C.A. Mathijsen, Willem Vreuls, Joris J. J. P. M. van de Leur, B. A. J. Veldman, Jacqueline M. Bos,
Tópico(s)Renal function and acid-base balance
ResumoIon-exchange resins like sodium polystyrene sulfonate (Resonium A®; SPS), calcium polystyrene sulfonate (Sorbisterit®; CPS) and sevelamer (Renvela®) are treatments for management of the electrolyte disturbances hyperkalemia and hyperphosphatemia. SPS and CPS are associated with GI adverse events (necrosis of the bowel wall, ulceration and perforation) with a high mortality rate. There is a number of predisposing factors for developing GI injury due to SPS or CPS (postoperative state, renal failure and transplantation).
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