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Genetics of the low density lipoprotein receptor:

1981; Wiley; Volume: 20; Issue: 2 Linguagem: Inglês

10.1111/j.1399-0004.1981.tb01815.x

1399-0004

Per Magnus, Kjell Maartmann‐Moe, Wendy L. Golden, Walter E. Nance, Kåre Berg,

Protease and Inhibitor Mechanisms

Fibroblast low density lipoprotein (LDL) plasma membrane receptor activity, measured as 125I-LDL association (plasma membrane binding plus intracellular accumulation) and degradation was determined in cell strains from 14 monozygotic (MZ) and 21 like-sexed dizygotic (DZ) normolipidemic twin pairs. The twins were between 57 and 62 years old and had liver apart for an average of 38 years (range 0-60). The intrapair differences were significantly smaller in MZ than in DZ twin pairs in fibroblast 125I-LDL association as well as degradation assays (P less than 0.05). These findings suggest a genetic influence on normal variation in LDL receptor activity in vitro. In two MZ pairs discordant for psoriasis, the psoriatic twin had markedly lower LDL receptor activity than the cotwin.