Association of abnormal smooth pursuit eye movements with the deficit syndrome in schizophrenic patients
1996; American Psychiatric Association; Volume: 153; Issue: 9 Linguagem: Inglês
10.1176/ajp.153.9.1158
ISSN1535-7228
AutoresDavid E. Ross, Gunvant K. Thaker, Robert W. Buchanan, Adrienne C. Lahti, Deborah R. Medoff, John J. Bartko, Marianne Moran, Julie Hartley,
Tópico(s)Psychosomatic Disorders and Their Treatments
ResumoBack to table of contents Previous article Next article No AccessAssociation of abnormal smooth pursuit eye movements with the deficit syndrome in schizophrenic patientsPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.153.9.1158AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: The authors' goal was to test the hypothesis that abnormal smooth pursuit eye movements in schizophrenic patients are associated with the deficit syndrome. METHOD: The eye movements of 24 normal comparison subjects, 32 patients with nondeficit schizophrenia, and 11 patients with deficit schizophrenia were tested with infrared oculography using foveapetal step-ramp targets. RESULTS: The group of schizophrenic patients had normal latency to pursuit onset, abnormally decreased open-loop acceleration and abnormally decreased velocity during the periods of closed-loop acceleration and steady-state pursuit. The subgroup of schizophrenic patients with the deficit syndrome had particularly poor performance during the periods of open- and closed-loop acceleration. CONCLUSIONS: Patients with schizophrenia have abnormal smooth pursuit eye movements in response to a step-ramp stimulus, and the defects are particularly pronounced in patients with the deficit syndrome. Abnormal smooth pursuit eye movements in schizophrenia and related disorders have been consistently linked with primary and enduring negative symptoms. Access content To read the fulltext, please use one of the options below to sign in or purchase access. 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FiguresReferencesCited byDetailsCited byCurrent development in wearable glucose metersChinese Chemical Letters, Vol. 32, No. 12Oculomotricity and Neurological Soft Signs: Can we refine the endophenotype? 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