Validity of Vascular Calcification as a Screening Tool and as a Surrogate End Point in Clinical Research
2015; Lippincott Williams & Wilkins; Volume: 66; Issue: 1 Linguagem: Inglês
10.1161/hypertensionaha.115.04801
ISSN1524-4563
AutoresCarmine Zoccali, Davide Bolignano, Graziella D’Arrigo, Friedo W. Dekker, Danilo Fliser, Gunnar H. Heine, Kitty J. Jager, Mehmet Kanbay, Francesca Mallamaci, Ziad A. Massy, Alberto Ortíz, Gianfranco Parati, Patrick Rossignol, Giovanni Tripepi, Raymond Vanholder, Andrzej Więcek, Gérard M. London,
Tópico(s)Renal and Vascular Pathologies
ResumoHomeHypertensionVol. 66, No. 1Validity of Vascular Calcification as a Screening Tool and as a Surrogate End Point in Clinical Research Free AccessResearch ArticlePDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissionsDownload Articles + Supplements ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toSupplemental MaterialFree AccessResearch ArticlePDF/EPUBValidity of Vascular Calcification as a Screening Tool and as a Surrogate End Point in Clinical Research Carmine Zoccali, Davide Bolignano, Graziella D'Arrigo, Friedo W Dekker, Danilo Fliser, Gunnar H. Heine, Kitty J. Jager, Mehmet Kanbay, Francesca Mallamaci, Ziad Massy, Alberto Ortiz, Gianfranco Parati, Patrick Rossignol, Giovanni Tripepi, Raymond Vanholder, Andrzej Wiecek and Gerard Londonon behalf of the European Renal and Cardiovascular Medicine (EURECA-m) Working Group of the European Renal Association–European Dialysis Transplantation Association (ERA-EDTA) Carmine ZoccaliCarmine Zoccali From the CNR-IFC Pathophysiology of Renal Diseases and Hypertension Unit, Reggio Calabria, Italy (C.Z., D.B., G.D'A., F.M., G.T.); Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands (F.W.D.); Department of Internal Medicine IV, Saarland University Medical Centre, Homburg/Saar, Germany (D.F., G.H.H.); Department of Medical Informatics, Academic Medical Center, European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, University of Amsterdam, Amsterdam, The Netherlands (K.J.J.); Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey (M.K.); Nephrology, Dialysis, and Transplantation Unit and CNR-IFC Clinical Epidemiology, Reggio Calabria, Italy (F.M.); Paris Ile de France Ouest (UVSQ) University, Paris, France (Z.M.); Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain (A.O.); Department of Cardiovascular, Neural, and Metabolic Sciences, S. Luca Hospital, Istituto Auxologico Italiano & University of Milan-Bicocca, Milan, Italy (G.P.); INSERM, Centre d'Investigations Cliniques-Plurithématique 1433, INSERM U1116, Nancy, France (P.R.); Département de Cardiologie, CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, France (P.R.); Université de Lorraine, Nancy, France (P.R.); INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R.); Division of Nephrology, Department of Internal Medicine, Ghent University Hospital, University Hospital Gent, Ghent, Belgium (R.V.); Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland (A.W.); and INSERM U970, Hopital Européen Georges Pompidou, Paris, France (G.L.). , Davide BolignanoDavide Bolignano From the CNR-IFC Pathophysiology of Renal Diseases and Hypertension Unit, Reggio Calabria, Italy (C.Z., D.B., G.D'A., F.M., G.T.); Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands (F.W.D.); Department of Internal Medicine IV, Saarland University Medical Centre, Homburg/Saar, Germany (D.F., G.H.H.); Department of Medical Informatics, Academic Medical Center, European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, University of Amsterdam, Amsterdam, The Netherlands (K.J.J.); Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey (M.K.); Nephrology, Dialysis, and Transplantation Unit and CNR-IFC Clinical Epidemiology, Reggio Calabria, Italy (F.M.); Paris Ile de France Ouest (UVSQ) University, Paris, France (Z.M.); Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain (A.O.); Department of Cardiovascular, Neural, and Metabolic Sciences, S. Luca Hospital, Istituto Auxologico Italiano & University of Milan-Bicocca, Milan, Italy (G.P.); INSERM, Centre d'Investigations Cliniques-Plurithématique 1433, INSERM U1116, Nancy, France (P.R.); Département de Cardiologie, CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, France (P.R.); Université de Lorraine, Nancy, France (P.R.); INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R.); Division of Nephrology, Department of Internal Medicine, Ghent University Hospital, University Hospital Gent, Ghent, Belgium (R.V.); Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland (A.W.); and INSERM U970, Hopital Européen Georges Pompidou, Paris, France (G.L.). , Graziella D'ArrigoGraziella D'Arrigo From the CNR-IFC Pathophysiology of Renal Diseases and Hypertension Unit, Reggio Calabria, Italy (C.Z., D.B., G.D'A., F.M., G.T.); Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands (F.W.D.); Department of Internal Medicine IV, Saarland University Medical Centre, Homburg/Saar, Germany (D.F., G.H.H.); Department of Medical Informatics, Academic Medical Center, European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, University of Amsterdam, Amsterdam, The Netherlands (K.J.J.); Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey (M.K.); Nephrology, Dialysis, and Transplantation Unit and CNR-IFC Clinical Epidemiology, Reggio Calabria, Italy (F.M.); Paris Ile de France Ouest (UVSQ) University, Paris, France (Z.M.); Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain (A.O.); Department of Cardiovascular, Neural, and Metabolic Sciences, S. Luca Hospital, Istituto Auxologico Italiano & University of Milan-Bicocca, Milan, Italy (G.P.); INSERM, Centre d'Investigations Cliniques-Plurithématique 1433, INSERM U1116, Nancy, France (P.R.); Département de Cardiologie, CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, France (P.R.); Université de Lorraine, Nancy, France (P.R.); INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R.); Division of Nephrology, Department of Internal Medicine, Ghent University Hospital, University Hospital Gent, Ghent, Belgium (R.V.); Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland (A.W.); and INSERM U970, Hopital Européen Georges Pompidou, Paris, France (G.L.). , Friedo W DekkerFriedo W Dekker From the CNR-IFC Pathophysiology of Renal Diseases and Hypertension Unit, Reggio Calabria, Italy (C.Z., D.B., G.D'A., F.M., G.T.); Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands (F.W.D.); Department of Internal Medicine IV, Saarland University Medical Centre, Homburg/Saar, Germany (D.F., G.H.H.); Department of Medical Informatics, Academic Medical Center, European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, University of Amsterdam, Amsterdam, The Netherlands (K.J.J.); Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey (M.K.); Nephrology, Dialysis, and Transplantation Unit and CNR-IFC Clinical Epidemiology, Reggio Calabria, Italy (F.M.); Paris Ile de France Ouest (UVSQ) University, Paris, France (Z.M.); Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain (A.O.); Department of Cardiovascular, Neural, and Metabolic Sciences, S. Luca Hospital, Istituto Auxologico Italiano & University of Milan-Bicocca, Milan, Italy (G.P.); INSERM, Centre d'Investigations Cliniques-Plurithématique 1433, INSERM U1116, Nancy, France (P.R.); Département de Cardiologie, CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, France (P.R.); Université de Lorraine, Nancy, France (P.R.); INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R.); Division of Nephrology, Department of Internal Medicine, Ghent University Hospital, University Hospital Gent, Ghent, Belgium (R.V.); Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland (A.W.); and INSERM U970, Hopital Européen Georges Pompidou, Paris, France (G.L.). , Danilo FliserDanilo Fliser From the CNR-IFC Pathophysiology of Renal Diseases and Hypertension Unit, Reggio Calabria, Italy (C.Z., D.B., G.D'A., F.M., G.T.); Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands (F.W.D.); Department of Internal Medicine IV, Saarland University Medical Centre, Homburg/Saar, Germany (D.F., G.H.H.); Department of Medical Informatics, Academic Medical Center, European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, University of Amsterdam, Amsterdam, The Netherlands (K.J.J.); Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey (M.K.); Nephrology, Dialysis, and Transplantation Unit and CNR-IFC Clinical Epidemiology, Reggio Calabria, Italy (F.M.); Paris Ile de France Ouest (UVSQ) University, Paris, France (Z.M.); Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain (A.O.); Department of Cardiovascular, Neural, and Metabolic Sciences, S. Luca Hospital, Istituto Auxologico Italiano & University of Milan-Bicocca, Milan, Italy (G.P.); INSERM, Centre d'Investigations Cliniques-Plurithématique 1433, INSERM U1116, Nancy, France (P.R.); Département de Cardiologie, CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, France (P.R.); Université de Lorraine, Nancy, France (P.R.); INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R.); Division of Nephrology, Department of Internal Medicine, Ghent University Hospital, University Hospital Gent, Ghent, Belgium (R.V.); Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland (A.W.); and INSERM U970, Hopital Européen Georges Pompidou, Paris, France (G.L.). , Gunnar H. HeineGunnar H. Heine From the CNR-IFC Pathophysiology of Renal Diseases and Hypertension Unit, Reggio Calabria, Italy (C.Z., D.B., G.D'A., F.M., G.T.); Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands (F.W.D.); Department of Internal Medicine IV, Saarland University Medical Centre, Homburg/Saar, Germany (D.F., G.H.H.); Department of Medical Informatics, Academic Medical Center, European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, University of Amsterdam, Amsterdam, The Netherlands (K.J.J.); Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey (M.K.); Nephrology, Dialysis, and Transplantation Unit and CNR-IFC Clinical Epidemiology, Reggio Calabria, Italy (F.M.); Paris Ile de France Ouest (UVSQ) University, Paris, France (Z.M.); Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain (A.O.); Department of Cardiovascular, Neural, and Metabolic Sciences, S. Luca Hospital, Istituto Auxologico Italiano & University of Milan-Bicocca, Milan, Italy (G.P.); INSERM, Centre d'Investigations Cliniques-Plurithématique 1433, INSERM U1116, Nancy, France (P.R.); Département de Cardiologie, CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, France (P.R.); Université de Lorraine, Nancy, France (P.R.); INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R.); Division of Nephrology, Department of Internal Medicine, Ghent University Hospital, University Hospital Gent, Ghent, Belgium (R.V.); Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland (A.W.); and INSERM U970, Hopital Européen Georges Pompidou, Paris, France (G.L.). , Kitty J. JagerKitty J. Jager From the CNR-IFC Pathophysiology of Renal Diseases and Hypertension Unit, Reggio Calabria, Italy (C.Z., D.B., G.D'A., F.M., G.T.); Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands (F.W.D.); Department of Internal Medicine IV, Saarland University Medical Centre, Homburg/Saar, Germany (D.F., G.H.H.); Department of Medical Informatics, Academic Medical Center, European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, University of Amsterdam, Amsterdam, The Netherlands (K.J.J.); Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey (M.K.); Nephrology, Dialysis, and Transplantation Unit and CNR-IFC Clinical Epidemiology, Reggio Calabria, Italy (F.M.); Paris Ile de France Ouest (UVSQ) University, Paris, France (Z.M.); Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain (A.O.); Department of Cardiovascular, Neural, and Metabolic Sciences, S. Luca Hospital, Istituto Auxologico Italiano & University of Milan-Bicocca, Milan, Italy (G.P.); INSERM, Centre d'Investigations Cliniques-Plurithématique 1433, INSERM U1116, Nancy, France (P.R.); Département de Cardiologie, CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, France (P.R.); Université de Lorraine, Nancy, France (P.R.); INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R.); Division of Nephrology, Department of Internal Medicine, Ghent University Hospital, University Hospital Gent, Ghent, Belgium (R.V.); Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland (A.W.); and INSERM U970, Hopital Européen Georges Pompidou, Paris, France (G.L.). , Mehmet KanbayMehmet Kanbay From the CNR-IFC Pathophysiology of Renal Diseases and Hypertension Unit, Reggio Calabria, Italy (C.Z., D.B., G.D'A., F.M., G.T.); Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands (F.W.D.); Department of Internal Medicine IV, Saarland University Medical Centre, Homburg/Saar, Germany (D.F., G.H.H.); Department of Medical Informatics, Academic Medical Center, European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, University of Amsterdam, Amsterdam, The Netherlands (K.J.J.); Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey (M.K.); Nephrology, Dialysis, and Transplantation Unit and CNR-IFC Clinical Epidemiology, Reggio Calabria, Italy (F.M.); Paris Ile de France Ouest (UVSQ) University, Paris, France (Z.M.); Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain (A.O.); Department of Cardiovascular, Neural, and Metabolic Sciences, S. Luca Hospital, Istituto Auxologico Italiano & University of Milan-Bicocca, Milan, Italy (G.P.); INSERM, Centre d'Investigations Cliniques-Plurithématique 1433, INSERM U1116, Nancy, France (P.R.); Département de Cardiologie, CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, France (P.R.); Université de Lorraine, Nancy, France (P.R.); INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R.); Division of Nephrology, Department of Internal Medicine, Ghent University Hospital, University Hospital Gent, Ghent, Belgium (R.V.); Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland (A.W.); and INSERM U970, Hopital Européen Georges Pompidou, Paris, France (G.L.). , Francesca MallamaciFrancesca Mallamaci From the CNR-IFC Pathophysiology of Renal Diseases and Hypertension Unit, Reggio Calabria, Italy (C.Z., D.B., G.D'A., F.M., G.T.); Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands (F.W.D.); Department of Internal Medicine IV, Saarland University Medical Centre, Homburg/Saar, Germany (D.F., G.H.H.); Department of Medical Informatics, Academic Medical Center, European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, University of Amsterdam, Amsterdam, The Netherlands (K.J.J.); Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey (M.K.); Nephrology, Dialysis, and Transplantation Unit and CNR-IFC Clinical Epidemiology, Reggio Calabria, Italy (F.M.); Paris Ile de France Ouest (UVSQ) University, Paris, France (Z.M.); Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain (A.O.); Department of Cardiovascular, Neural, and Metabolic Sciences, S. Luca Hospital, Istituto Auxologico Italiano & University of Milan-Bicocca, Milan, Italy (G.P.); INSERM, Centre d'Investigations Cliniques-Plurithématique 1433, INSERM U1116, Nancy, France (P.R.); Département de Cardiologie, CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, France (P.R.); Université de Lorraine, Nancy, France (P.R.); INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R.); Division of Nephrology, Department of Internal Medicine, Ghent University Hospital, University Hospital Gent, Ghent, Belgium (R.V.); Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland (A.W.); and INSERM U970, Hopital Européen Georges Pompidou, Paris, France (G.L.). , Ziad MassyZiad Massy From the CNR-IFC Pathophysiology of Renal Diseases and Hypertension Unit, Reggio Calabria, Italy (C.Z., D.B., G.D'A., F.M., G.T.); Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands (F.W.D.); Department of Internal Medicine IV, Saarland University Medical Centre, Homburg/Saar, Germany (D.F., G.H.H.); Department of Medical Informatics, Academic Medical Center, European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, University of Amsterdam, Amsterdam, The Netherlands (K.J.J.); Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey (M.K.); Nephrology, Dialysis, and Transplantation Unit and CNR-IFC Clinical Epidemiology, Reggio Calabria, Italy (F.M.); Paris Ile de France Ouest (UVSQ) University, Paris, France (Z.M.); Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain (A.O.); Department of Cardiovascular, Neural, and Metabolic Sciences, S. Luca Hospital, Istituto Auxologico Italiano & University of Milan-Bicocca, Milan, Italy (G.P.); INSERM, Centre d'Investigations Cliniques-Plurithématique 1433, INSERM U1116, Nancy, France (P.R.); Département de Cardiologie, CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, France (P.R.); Université de Lorraine, Nancy, France (P.R.); INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R.); Division of Nephrology, Department of Internal Medicine, Ghent University Hospital, University Hospital Gent, Ghent, Belgium (R.V.); Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland (A.W.); and INSERM U970, Hopital Européen Georges Pompidou, Paris, France (G.L.). , Alberto OrtizAlberto Ortiz From the CNR-IFC Pathophysiology of Renal Diseases and Hypertension Unit, Reggio Calabria, Italy (C.Z., D.B., G.D'A., F.M., G.T.); Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands (F.W.D.); Department of Internal Medicine IV, Saarland University Medical Centre, Homburg/Saar, Germany (D.F., G.H.H.); Department of Medical Informatics, Academic Medical Center, European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, University of Amsterdam, Amsterdam, The Netherlands (K.J.J.); Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey (M.K.); Nephrology, Dialysis, and Transplantation Unit and CNR-IFC Clinical Epidemiology, Reggio Calabria, Italy (F.M.); Paris Ile de France Ouest (UVSQ) University, Paris, France (Z.M.); Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain (A.O.); Department of Cardiovascular, Neural, and Metabolic Sciences, S. Luca Hospital, Istituto Auxologico Italiano & University of Milan-Bicocca, Milan, Italy (G.P.); INSERM, Centre d'Investigations Cliniques-Plurithématique 1433, INSERM U1116, Nancy, France (P.R.); Département de Cardiologie, CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, France (P.R.); Université de Lorraine, Nancy, France (P.R.); INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R.); Division of Nephrology, Department of Internal Medicine, Ghent University Hospital, University Hospital Gent, Ghent, Belgium (R.V.); Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland (A.W.); and INSERM U970, Hopital Européen Georges Pompidou, Paris, France (G.L.). , Gianfranco ParatiGianfranco Parati From the CNR-IFC Pathophysiology of Renal Diseases and Hypertension Unit, Reggio Calabria, Italy (C.Z., D.B., G.D'A., F.M., G.T.); Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands (F.W.D.); Department of Internal Medicine IV, Saarland University Medical Centre, Homburg/Saar, Germany (D.F., G.H.H.); Department of Medical Informatics, Academic Medical Center, European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, University of Amsterdam, Amsterdam, The Netherlands (K.J.J.); Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey (M.K.); Nephrology, Dialysis, and Transplantation Unit and CNR-IFC Clinical Epidemiology, Reggio Calabria, Italy (F.M.); Paris Ile de France Ouest (UVSQ) University, Paris, France (Z.M.); Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain (A.O.); Department of Cardiovascular, Neural, and Metabolic Sciences, S. Luca Hospital, Istituto Auxologico Italiano & University of Milan-Bicocca, Milan, Italy (G.P.); INSERM, Centre d'Investigations Cliniques-Plurithématique 1433, INSERM U1116, Nancy, France (P.R.); Département de Cardiologie, CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, France (P.R.); Université de Lorraine, Nancy, France (P.R.); INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R.); Division of Nephrology, Department of Internal Medicine, Ghent University Hospital, University Hospital Gent, Ghent, Belgium (R.V.); Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland (A.W.); and INSERM U970, Hopital Européen Georges Pompidou, Paris, France (G.L.). , Patrick RossignolPatrick Rossignol From the CNR-IFC Pathophysiology of Renal Diseases and Hypertension Unit, Reggio Calabria, Italy (C.Z., D.B., G.D'A., F.M., G.T.); Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands (F.W.D.); Department of Internal Medicine IV, Saarland University Medical Centre, Homburg/Saar, Germany (D.F., G.H.H.); Department of Medical Informatics, Academic Medical Center, European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, University of Amsterdam, Amsterdam, The Netherlands (K.J.J.); Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey (M.K.); Nephrology, Dialysis, and Transplantation Unit and CNR-IFC Clinical Epidemiology, Reggio Calabria, Italy (F.M.); Paris Ile de France Ouest (UVSQ) University, Paris, France (Z.M.); Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain (A.O.); Department of Cardiovascular, Neural, and Metabolic Sciences, S. Luca Hospital, Istituto Auxologico Italiano & University of Milan-Bicocca, Milan, Italy (G.P.); INSERM, Centre d'Investigations Cliniques-Plurithématique 1433, INSERM U1116, Nancy, France (P.R.); Département de Cardiologie, CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, France (P.R.); Université de Lorraine, Nancy, France (P.R.); INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R.); Division of Nephrology, Department of Internal Medicine, Ghent University Hospital, University Hospital Gent, Ghent, Belgium (R.V.); Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland (A.W.); and INSERM U970, Hopital Européen Georges Pompidou, Paris, France (G.L.). , Giovanni TripepiGiovanni Tripepi From the CNR-IFC Pathophysiology of Renal Diseases and Hypertension Unit, Reggio Calabria, Italy (C.Z., D.B., G.D'A., F.M., G.T.); Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands (F.W.D.); Department of Internal Medicine IV, Saarland University Medical Centre, Homburg/Saar, Germany (D.F., G.H.H.); Department of Medical Informatics, Academic Medical Center, European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, University of Amsterdam, Amsterdam, The Netherlands (K.J.J.); Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey (M.K.); Nephrology, Dialysis, and Transplantation Unit and CNR-IFC Clinical Epidemiology, Reggio Calabria, Italy (F.M.); Paris Ile de France Ouest (UVSQ) University, Paris, France (Z.M.); Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain (A.O.); Department of Cardiovascular, Neural, and Metabolic Sciences, S. Luca Hospital, Istituto Auxologico Italiano & University of Milan-Bicocca, Milan, Italy (G.P.); INSERM, Centre d'Investigations Cliniques-Plurithématique 1433, INSERM U1116, Nancy, France (P.R.); Département de Cardiologie, CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, France (P.R.); Université de Lorraine, Nancy, France (P.R.); INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R.); Division of Nephrology, Department of Internal Medicine, Ghent University Hospital, University Hospital Gent, Ghent, Belgium (R.V.); Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland (A.W.); and INSERM U970, Hopital Européen Georges Pompidou, Paris, France (G.L.). , Raymond VanholderRaymond Vanholder From the CNR-IFC Pathophysiology of Renal Diseases and Hypertension Unit, Reggio Calabria, Italy (C.Z., D.B., G.D'A., F.M., G.T.); Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands (F.W.D.); Department of Internal Medicine IV, Saarland University Medical Centre, Homburg/Saar, Germany (D.F., G.H.H.); Department of Medical Informatics, Academic Medical Center, European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, University of Amsterdam, Amsterdam, The Netherlands (K.J.J.); Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey (M.K.); Nephrology, Dialysis, and Transplantation Unit and CNR-IFC Clinical Epidemiology, Reggio Calabria, Italy (F.M.); Paris Ile de France Ouest (UVSQ) University, Paris, France (Z.M.); Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain (A.O.); Department of Cardiovascular, Neural, and Metabolic Sciences, S. Luca Hospital, Istituto Auxologico Italiano & University of Milan-Bicocca, Milan, Italy (G.P.); INSERM, Centre d'Investigations Cliniques-Plurithématique 1433, INSERM U1116, Nancy, France (P.R.); Département de Cardiologie, CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, France (P.R.); Université de Lorraine, Nancy, France (P.R.); INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R.); Division of Nephrology, Department of Internal Medicine, Ghent University Hospital, University Hospital Gent, Ghent, Belgium (R.V.); Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland (A.W.); and INSERM U970, Hopital Européen Georges Pompidou, Paris, France (G.L.). , Andrzej WiecekAndrzej Wiecek From the CNR-IFC Pathophysiology of Renal Diseases and Hypertension Unit, Reggio Calabria, Italy (C.Z., D.B., G.D'A., F.M., G.T.); Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands (F.W.D.); Department of Internal Medicine IV, Saarland University Medical Centre, Homburg/Saar, Germany (D.F., G.H.H.); Department of Medical Informatics, Academic Medical Center, European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, University of Amsterdam, Amsterdam, The Netherlands (K.J.J.); Division of Nephrology, Department
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