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Beta Interferon Is Produced by Chlamydia trachomatis -Infected Fibroblast-Like Synoviocytes and Inhibits Gamma Interferon-Induced HLA-DR Expression

1998; American Society for Microbiology; Volume: 66; Issue: 9 Linguagem: Inglês

10.1128/iai.66.9.4491-4495.1998

1098-5522

Jürgen Rödel, A Groh, Heinz Vogelsang, Marc Lehmann, Matthias Hartmann, Eberhard Straube,

T-cell and B-cell Immunology

ABSTRACT Infection of fibroblast-like synovial cells with Chlamydia trachomatis (serotype D strain IC Cal 8) in culture induced the secretion of beta interferon (IFN-β). Chlamydial infection inhibited IFN-γ-induced expression of HLA-DR antigen in the cells. Addition of IFN-β antibody directly to infected cultures mitigated HLA-DR inhibition, suggesting involvement of produced IFN-β.