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Cholinesterase Inhibitors: An Overview of their Mechanisms of Action

1997; Linguagem: Inglês

10.1007/978-1-4612-4116-4_31

Albert Enz, Philipp Floersheim,

Chemical synthesis and alkaloids

Alzheimer's disease (AD) is a degenerative disorder of the CNS which will become a major health problem in the following decades. AD is associated with a decrease of cholinergic activity in the cortex and other brain regions. Of the different approaches to reversing the cholinergic deficit, the inhibition of acetylcholinesterase (AChE) seems to produce symptomatic improvements in clinical trials (Whitehouse, 1993).