Presence of AntiTissue Transglutaminase Antibodies as a Sign of Tissue Lesion
2002; American Association for Clinical Chemistry; Volume: 48; Issue: 2 Linguagem: Inglês
10.1093/clinchem/48.2.393
ISSN1530-8561
AutoresMarco Di Tola, L. Sabbatella, Antonio Picarelli,
Tópico(s)Immunodeficiency and Autoimmune Disorders
ResumoWe read with interest the report (1) on IgG antibodies against tissue transglutaminase (tTG) in patients positive for anti-double-stranded DNA with systemic lupus erythematosus and in patients positive for anti-SSA/SSB. We agree with the authors’ hypothesis that in some autoimmune disorders, such as systemic lupus erythematosus, the content of apoptotic bodies (including tTG) could come into contact with the immune system, leading to an autoimmune response. Nevertheless, some aspects of this study require comments. tTG, an intracellular enzyme, has recently been proposed as the major autoantigen of anti-endomysial antibodies (EMAs), and measurements of IgA anti-tTG antibodies are used in the diagnostic evaluation of … [↵][1]bAuthor for correspondence. Fax 31-53-487-3075; e-mail labmst{at}euronet.nl. [1]: #xref-corresp-2-1
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