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The spectrum of movement disorders in children with anti‐ NMDA receptor encephalitis

2013; Wiley; Volume: 28; Issue: 4 Linguagem: Inglês

10.1002/mds.25354

1531-8257

José Fidel Baizabal‐Carvallo, Amber Stocco, Eyal Muscal, Joseph Jankovic,

Ion channel regulation and function

ABSTRACT Background Movement disorders are frequent but difficult to characterize in patients with anti‐ N ‐methyl‐ d ‐aspartate receptor ( NMDAR ) encephalitis. Methods The phenomenology of movement disorders was characterized after a detailed examination of children with anti‐ NMDAR ‐encephalitis. Results We studied 9 children (5 females), ages 3–14 years, with confirmed anti‐ NMDAR ‐encephalitis. All patients presented with at least 1 movement disorder, including chorea (n=4), stereotypic movements (n=4), ataxia (n=3), limb dystonia (n=2), limb myorhythmia (n=2), oromandibular dystonia (n=2), facial myorhythmia, blepharospasm, opisthotonus, athetosis, and tremor (n=1, each). More than a single movement disorder was observed in 6 of these patients. Resolution of the abnormal movements was observed in all patients with immunotherapy; 1 patient improved with tetrabenazine. Conclusions A wide variety of movement disorders, often in combination, can be observed in children with anti‐ NMDAR encephalitis. Patients commonly present with more than a single movement disorder. © 2013 Movement Disorder Society