Portal de Periódicos da CAPES

Emergence of Atrial Repolarization Alternans at Late Stages of Remodeling: The “Second Factor” in Atrial Fibrillation Progression?

2014; Wiley; Volume: 25; Issue: 4 Linguagem: Inglês

10.1111/jce.12377

1540-8167

Fadi G. Akar,

Cardiac Arrhythmias and Treatments

Journal of Cardiovascular ElectrophysiologyVolume 25, Issue 4 p. 428-430 Editorial Comment Emergence of Atrial Repolarization Alternans at Late Stages of Remodeling: The “Second Factor” in Atrial Fibrillation Progression? FADI G. AKAR Ph.D., F.H.R.S., Corresponding Author FADI G. AKAR Ph.D., F.H.R.S. Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USAAddress for correspondence: Fadi G. Akar, Ph.D. F.H.R.S., Mount Sinai School of Medicine, One Gustave L. Levy Place, Atran Building, 511, New York, NY 10029, USA. Fax: 212-241-4080; E-mail: [email protected]Search for more papers by this author FADI G. AKAR Ph.D., F.H.R.S., Corresponding Author FADI G. AKAR Ph.D., F.H.R.S. Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USAAddress for correspondence: Fadi G. Akar, Ph.D. F.H.R.S., Mount Sinai School of Medicine, One Gustave L. Levy Place, Atran Building, 511, New York, NY 10029, USA. Fax: 212-241-4080; E-mail: [email protected]Search for more papers by this author First published: 30 January 2014 https://doi.org/10.1111/jce.12377Citations: 1 FGA is supported by grants from the NIH HL114378 and 119046 and the AHA 13GRNT17000046. No disclosures. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. References 1Go AS, Hylek EM, Phillips KA, Chang Y, Henault LE, Selby JV, Singer DE: Prevalence of diagnosed atrial fibrillation in adults: National implications for rhythm management and stroke prevention: The anticoagulation and risk factors in atrial fibrillation (ATRIA) study. J Am Med Assoc 2001; 285: 2370- 2375. 2Miyasaka Y, Barnes ME, Gersh BJ, Cha SS, Bailey KR, Abhayaratna WP, Seward JB, Tsang TS: Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence. Circulation 2006; 114: 119- 125. 3Fuster V: Atrial fibrillation: An epidemiologic, scientific and clinical challenge. Nat Clin Pract 2005; 2: 225. 4Fuster V, Ryden LE, Cannom DS, Crijns HJ, Curtis AB, Ellenbogen KA, Halperin JL, Le Heuzey JY, Kay GN, Lowe JE, Olsson SB, Prystowsky EN, Tamargo JL, Wann S, Smith SC Jr, Jacobs AK, Adams CD, Anderson JL, Antman EM, Halperin JL, Hunt SA, Nishimura R, Ornato JP, Page RL, Riegel B, Priori SG, Blanc JJ, Budaj A, Camm AJ, Dean V, Deckers JW, Despres C, Dickstein K, Lekakis J, McGregor K, Metra M, Morais J, Osterspey A, Tamargo JL, Zamorano JL: ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee for practice guidelines (writing committee to revise the 2001 guidelines for the management of patients with atrial fibrillation): Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation 2006; 114: e257- e354. 5Padanilam BJ, Prystowsky EN: Atrial fibrillation: Goals of therapy and management strategies to achieve the goals. Cardiol Clin 2009; 27: 189- 200. 6Allessie MA, Boyden PA, Camm AJ, Kleber AG, Lab MJ, Legato MJ, Rosen MR, Schwartz PJ, Spooner PM, Van Wagoner DR, Waldo AL: Pathophysiology and prevention of atrial fibrillation. Circulation 2001; 103: 769- 777. 7Haissaguerre M, Jais P, Shah DC, Takahashi A, Hocini M, Quiniou G, Garrigue S, Le Mouroux A, Le Metayer P, Clementy J: Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med 1998; 339: 659- 666. 8Haissaguerre M, Shah DC, Jais P, Clementy J: Role of catheter ablation for atrial fibrillation. Curr Opin Cardiol 1997; 12: 18- 23. 9Ehrlich JR, Cha TJ, Zhang L, Chartier D, Melnyk P, Hohnloser SH, Nattel S: Cellular electrophysiology of canine pulmonary vein cardiomyocytes: Action potential and ionic current properties. J Physiol 2003; 551: 801- 813. 10Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Muller FU, Schmitz W, Schotten U, Anderson ME, Valderrabano M, Dobrev D, Wehrens XH: Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest 2009; 119: 1940- 1951. 11Patterson E, Jackman WM, Beckman KJ, Lazzara R, Lockwood D, Scherlag BJ, Wu R, Po S: Spontaneous pulmonary vein firing in man: Relationship to tachycardia-pause early afterdepolarizations and triggered arrhythmia in canine pulmonary veins in vitro. J Cardiovasc Electrophysiol 2007; 18: 1067- 1075. 12Allessie MA: Atrial electrophysiologic remodeling: Another vicious circle? J Cardiovasc Electrophysiol 1998; 9: 1378- 1393. 13Everett TH, Li H, Mangrum JM, McRury ID, Mitchell MA, Redick JA, Haines DE: Electrical, morphological, and ultrastructural remodeling and reverse remodeling in a canine model of chronic atrial fibrillation. Circulation 2000; 102: 1454- 1460. 14Wijffels MC, Kirchhof CJ, Dorland R, Allessie MA: Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation 1995; 92: 1954- 1968. 15Li D, Shinagawa K, Pang L, Leung TK, Cardin S, Wang Z, Nattel S: Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failure. Circulation 2001; 104: 2608- 2614. 16Kumagai K, Nakashima H, Urata H, Gondo N, Arakawa K, Saku K: Effects of angiotensin II type 1 receptor antagonist on electrical and structural remodeling in atrial fibrillation. J Am Coll Cardiol 2003; 41: 2197- 2204. 17Monigatti-Tenkorang J, Jousset F, Pascale P, Vesin JM, Ruchat P, Fromer M, Narayan SM, Pruvot E: Intermittent atrial tachycardia promotes repolarization alternans and conduction slowing during rapid rates, and increases susceptibility to atrial fibrillation in a free-behaving sheep model. J Cardiovasc Electrophysiol 2014; 25:doi:10.1111/jce.12353. 18Pastore JM, Girouard SD, Laurita KR, Akar FG, Rosenbaum DS: Mechanism linking T-wave alternans to the genesis of cardiac fibrillation. Circulation 1999; 99: 1385- 1394. 19Jousset F, Tenkorang J, Vesin JM, Pascale P, Ruchat P, Rollin AG, Fromer M, Narayan SM, Pruvot E: Kinetics of atrial repolarization alternans in a free-behaving ovine model. J Cardiovasc Electrophysiol 2013; 23: 1003- 1012. Citing Literature Volume25, Issue4April 2014Pages 428-430 ReferencesRelatedInformation