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BIBTEX RIS

Effectiveness and risk factors for virological outcome of darunavir-based therapy for treatment-experienced HIV-infected patients

2015; BioMed Central; Volume: 12; Issue: 1 Linguagem: Inglês

10.1186/s12981-015-0072-9

ISSN

1742-6405

Autores

José Antonio Mata‐Marín, Gloria Huerta-García, Juan Carlos Domínguez-Hermosillo, Marcelino Chávez-García, Marco Isaac Banda-Lara, Nohemí Núñez-Rodríguez, Javier Enrique Cruz-Herrera, Jorge Luis Sandoval-Ramírez, Martínez-Abarca Iván, Alfredo Villagómez-Ruiz, Bulmaro Manjarrez-Téllez, Jesús Gaytán‐Martínez,

Tópico(s)

Hepatitis C virus research

Resumo

We evaluated the effectiveness of darunavir (DRV) treatment plus an optimized background regimen in 120 HIV-1 treatment-experienced patients.Retrospective cohort, multicenter study.Adults >16 years with virological treatment failure starting therapy with a DRV-containing regimen were included. Effectiveness was evaluated as the percentage of patients with an undetectable HIV-1 RNA viral load (<50 and <200 copies/mL) after 48 weeks, and changes in CD4+ cell counts. We evaluated the risk factors associated with treatment failure.Of the cohort, 83 % were men with a median age of 45 years (interquartile range, IQR 40-51). They had experienced treatment for a median of 13 years (IQR 9-17) with a median of six previous regimens (IQR 4-7), all using protease inhibitors. After treatment, 82 % (95 % confidence interval, CI 74-88 %) of patients had an HIV-1 RNA viral load <200 copies/mL and 69 % (95 % CI 60-76 %) had <50 copies/mL. The CD4+ cell count increased by 378 cells/μL (IQR 252-559; P < 0.001 vs. baseline). Risk factors associated with poor outcome were age >40 years [odds ratio, OR 0.15 (95 % CI 0.10-0.78); P = 0.015], use of raltegravir in the regimen [OR 0.37 (95 % CI 0.10-0.97); P = 0.046], and baseline CD4+ cell count <200 cells/μL [OR 2.79 (95 % CI 1.11-6.97); P = 0.028].In this Mexican cohort Darunavir was metabolically safe, well tolerated and achieved high rates of virological suppression in highly treatment-experienced patients infected with HIV-1.

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