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Protection of rabbits in an infection model of toxic shock syndrome (TSS) by a TSS toxin-1-specific monoclonal antibody

1988; American Society for Microbiology; Volume: 56; Issue: 4 Linguagem: Inglês

10.1128/iai.56.4.998-999.1988

1098-5522

Gary K. Best, David F. Scott, James Kling, Michael R. Thompson, Luigi Elio Adinolfi, Peter F. Bonventre,

Viral Infectious Diseases and Gene Expression in Insects

An anti-TSST-1-specific monoclonal antibody (MAb 8-5-7) was tested for its protective capacity in a rabbit infection model to toxic shock syndrome (TSS). The challenge strain of Staphylococcus aureus (RN4710), which contained a plasmid encoding TSS toxin-1, was introduced into previously implanted chambers. Purified monoclonal antibody (1.25 mg of immunoglobulin G) administered parenterally 1 day before and 1 day after initiation of infection provided complete protection against the TSS-like syndrome and the mortality which occurred in unprotected rabbits.