The Murine CAR Homolog Is a Receptor for Coxsackie B Viruses and Adenoviruses
1998; American Society for Microbiology; Volume: 72; Issue: 1 Linguagem: Inglês
10.1128/jvi.72.1.415-419.1998
ISSN1098-5514
AutoresJeffrey M. Bergelson, Anita Krithivas, Leo A. Celi, Gustavo Droguett, Marshall S. Horwitz, Thomas J. Wickham, Richard L. Crowell, Robert W. Finberg,
Tópico(s)Viral gastroenteritis research and epidemiology
ResumoComplementary DNA clones encoding the murine homolog (mCAR) of the human coxsackievirus and adenovirus receptor (CAR) were isolated. Nonpermissive CHO cells transfected with mCAR cDNA became susceptible to infection by coxsackieviruses B3 and B4 and showed increased susceptibility to adenovirus-mediated gene transfer. These results indicate that the same receptor is responsible for virus interactions with both murine and human cells. Analysis of receptor expression in human and murine tissues should be useful in defining factors governing virus tropism in vivo.
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