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Combination of platelet count and neutrophil to lymphocyte ratio is a useful predictor of postoperative survival in patients undergoing surgery for gastric cancer

2014; Wiley; Volume: 110; Issue: 8 Linguagem: Inglês

10.1002/jso.23753

1096-9098

Mitsuru Ishizuka, Yusuke Oyama, Akihito Abe, Keiichi Kubota,

Cancer, Lipids, and Metabolism

Journal of Surgical OncologyVolume 110, Issue 8 p. 935-941 Research Article Combination of platelet count and neutrophil to lymphocyte ratio is a useful predictor of postoperative survival in patients undergoing surgery for gastric cancer Mitsuru Ishizuka MD, Corresponding Author Mitsuru Ishizuka MD Department of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, Japan Correspondence to: Mitsuru Ishizuka, MD, Department of Gastroenterological Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan. Fax: +81-282-86-6317. E-mail: mm-ishizuka@umin.ac.jpSearch for more papers by this authorYusuke Oyama MD, Yusuke Oyama MD Department of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, JapanSearch for more papers by this authorAkihito Abe MD, Akihito Abe MD Department of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, JapanSearch for more papers by this authorKeiichi Kubota MD, Keiichi Kubota MD Department of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, JapanSearch for more papers by this author Mitsuru Ishizuka MD, Corresponding Author Mitsuru Ishizuka MD Department of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, Japan Correspondence to: Mitsuru Ishizuka, MD, Department of Gastroenterological Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan. Fax: +81-282-86-6317. E-mail: mm-ishizuka@umin.ac.jpSearch for more papers by this authorYusuke Oyama MD, Yusuke Oyama MD Department of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, JapanSearch for more papers by this authorAkihito Abe MD, Akihito Abe MD Department of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, JapanSearch for more papers by this authorKeiichi Kubota MD, Keiichi Kubota MD Department of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, JapanSearch for more papers by this author First published: 21 August 2014 https://doi.org/10.1002/jso.23753Citations: 50 The authors have no conflicts of interest to declare. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Objective To investigate the clinical utility of the Combination of Platelet count and Neutrophil to Lymphocyte Ratio (COP-NLR) for predicting the postoperative survival of patients undergoing surgery for gastric cancer (GC). Methods The COP-NLR was calculated on the basis of data obtained on the day of admission as follows: patients with both an elevated platelet count (>300 × 103/µl) and an elevated NLR (>3) were allocated a score of 2, and patients showing one or neither were allocated a score of 1 or 0, respectively. Five hundred forty-four patients for whom data were sufficient to allow analysis of the relationship between clinicolaboratory characteristics and postoperative survival were enrolled. Results Multivariate analysis using the 12 clinical characteristics selected by univariate analyses revealed that the COP-NLR was associated with OS (hazard ratio, 1.781; 95% C.I., 1.094–2.899; P = 0.020) along with age, tumor type, lymph node metastasis and albumin level. Kaplan–Meier analysis and log rank test demonstrated significant differences in both OS and cancer-specific survival among patients with COP-NLR 0, 1, and 2 (P < 0.001). Conclusion The COP-NLR is able to predict postoperative survival of patients with GC and classify such patients into three independent groups before surgery. J. Surg. Oncol. 2014; 110:935–941. © 2014 Wiley Periodicals, Inc. Citing Literature Volume110, Issue8December 15, 2014Pages 935-941 RelatedInformation