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In Vitro Effect of Sulfamethoxazole-Trimethoprim against Histoplasma capsulatum var. capsulatum

2010; American Society for Microbiology; Volume: 54; Issue: 9 Linguagem: Inglês

10.1128/aac.00793-10

1098-6596

Raimunda Sâmia Nogueira Brilhante, Maria Auxiliadora Bezerra Fechine, Rossana de Aguiar Cordeiro, Marcos Fábio Gadelha Rocha, Joyce Fonteles Ribeiro, André Jalles Monteiro, Rita Amanda Chaves de Lima, Jacó Ricarte Lima de Mesquita, Zoilo Pires dè Camargo, José Júlio Costa Sidrim,

Pneumocystis jirovecii pneumonia detection and treatment

ABSTRACT This study evaluated the in vitro effect of sulfamethoxazole-trimethoprim against Histoplasma capsulatum var. capsulatum isolated from HIV-positive patients. The drugs were tested by microdilution testing in accordance with the CLSI guidelines. All of the strains were inhibited by sulfamethoxazole-trimethoprim, with MIC ranges of 0.039 (sulfamethoxazole)/0.0078 (trimethoprim) mg/ml to 0.625/0.125 mg/ml for mycelial forms and 0.0025/0.0005 to 0.02/0.004 mg/ml for yeast-like forms. However, in vivo studies are necessary to evaluate the significance of these results.