Delayed maturation of the frontal cortex in childhood autism
1995; American Psychiatric Association; Volume: 152; Issue: 2 Linguagem: Inglês
10.1176/ajp.152.2.248
ISSN1535-7228
AutoresMônica Zilbovicius, B Garreau, Yves Samson, Philippe Rémy, Catherine Barthélémy, A. Syrota, G Lelord,
Tópico(s)Behavioral and Psychological Studies
ResumoBack to table of contents Previous article Next article No AccessDelayed maturation of the frontal cortex in childhood autismPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.152.2.248AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: The authors investigated the metabolic maturation of the frontal cortex in pre-school autistic children. METHOD: Regional cerebral blood flow (CBF) in five children with primary autism diagnosed according to the DSM-III-R criteria was studied longitudinally. Regional CBF in each of the autistic children was measured with single photon emission computed tomography twice during their development: at the age of 3-4 years and 3 years later. At each stage, the autistic children were compared to an age-matched comparison group of five nonautistic children with normal development. RESULTS: A transient frontal hypoperfusion was found in the autistic children at ages 3-4 years; this corresponded to the pattern of perfusion observed in much younger normal children. By the ages of 6-7, the autistic children's frontal perfusion had attained normal values. CONCLUSIONS: Since CBF patterns in children are related to maturational changes in brain function, these results indicate a delayed frontal maturation in childhood autism. Such a delayed brain maturational process is consistent with the clinical data and cognitive performance of autistic children. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. 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