Thermal analysis of lipoic acid and evaluation of the compatibility with excipientes
2009; Springer Science+Business Media; Volume: 99; Issue: 2 Linguagem: Inglês
10.1007/s10973-009-0351-6
ISSN1588-2926
AutoresMaría Alejandra Moyano, Adriana M. Broussalis, Adriana Segall,
Tópico(s)Advanced Polymer Synthesis and Characterization
ResumoDifferential scanning calorimetry (DSC) was used as a screening technique for assessing the compatibility of lipoic acid with some currently employed cosmetic excipients. In the first phase of the study DSC was used as a tool to detect any interaction. Based on the DSC results alone, methyl p-hydroxybenzoate, propyl p-hydroxybenzoate, butylated hydroxytoluene, non ionic self emulsifying wax, propylene glycol and acetylated lanolin were found to exhibit interaction with lipoic acid. Stressed binary mixtures (stored at 50 °C for 1 week) of lipoic acid and excipients were evaluated by HPLC. Binary mixtures were evaluated by IR spectroscopy.
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