Produção Nacional
Revisado por pares
The effect of essential oil of Syzygium cumini on the development of granulomatous infl ammation in mice
2013; Springer Science+Business Media; Volume: 23; Issue: 3 Linguagem: Inglês
10.1590/s0102-695x2013005000030
ISSN1981-528X
AutoresRachel Rocha Pinheiro Machado, D. F. Jardim, Andrezza Rodrigues De Souza, Elita Scio, Rodrigo Luiz Fabri, Arthur G. Carpanez, Richard Michael Grazul, José Paulo Rodrigues Furtado de Mendonça, B. Lesche, Fernando Monteiro Aarestrup,
Tópico(s)Piperaceae Chemical and Biological Studies
ResumoThe anti-inflammatory and apoptotic activity of the essential oil of Syzygium cumini (L.) Skeels, Myrtaceae, leaves was investigated in vivo. The antiinflammatory action and chronic granulomatous inflammation in BALB/c mice, intravenously infected with Mycobacterium bovis, BCG, (Bacillo Calmet Guerim), was judged by measuring and classifying the granulomas formed in the hepatic parenchyma. The degree of apoptosis in the inflammatory cells was also measured. A reduction in the granulomatous area and a change in the pattern of the granulomas were found. Anti-mycobacterial activity of the essential oil against M. bovis was detected in vitro by an interferometric method in liquid culture medium. The chemical constituents of the essential oil were determined by GC/MS. Higher yields of the essential oil of S. cumini leaves were obtained by extraction in a Clevenger apparatus when the fresh leaves were previously frozen as a pre-processing step. The essential oil obtained from this plant demonstrated a statistically significant and dramatic effect in the chosen model system.
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