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BIBTEX RIS

Cissampelos sympodialis Eichl. (Menispermaceae) inhibits anaphylactic shock reaction in murine allergic model

2005; Springer Science+Business Media; Volume: 15; Issue: 4 Linguagem: Inglês

10.1590/s0102-695x2005000400004

ISSN

1981-528X

Autores

Claudio Bezerra-Santos, L M Peçanha, Márcia Regina Piuvezam,

Tópico(s)

Advancements in Transdermal Drug Delivery

Resumo

The murine model of OVA-induced immediate allergic reaction was used to evaluate the effectiveness of intraperitoneal sub-acute treatment with the leaf hydroalcoholic extract of Cissampelos sympodialis (AFL) in the anaphylactic shock reaction, IgE production and the background proliferative response. BALB/c mice treated with AFL ranging from 200 to 400 mg/kg/day for 5 days before and during OVA-sensitization strongly reduced the animal death and promoted reduction in total and OVA-specific serum IgE level. Spleen cells from AFL-treated sensitized animals showed a decreased proliferative background response when compared with non-sensitized animals. These results demonstrated that sub-acute intraperitoneal treatment with Cissampelos sympodialis extract has an anti-allergic effect.

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