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A New Function of Human HtrA2 as an Amyloid-β Oligomerization Inhibitor

2009; IOS Press; Volume: 17; Issue: 2 Linguagem: Inglês

10.3233/jad-2009-1037

1875-8908

Joel Kooistra, Julijana Milojevic, Giuseppe Melacini, Joaquín Ortega,

Cerebrovascular and genetic disorders

Human HtrA2 is part of the HtrA family of ATP-independent serine proteases that are conserved in both prokaryotes and eukaryotes and localizes to the intermembrane space of the mitochondria. Several recent reports have suggested that HtrA2 is importa