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Amorphous metal–organic frameworks for drug delivery

2015; Royal Society of Chemistry; Volume: 51; Issue: 73 Linguagem: Inglês

10.1039/c5cc05237h

1364-548X

Claudia Orellana‐Tavra, Emma F. Baxter, Tian Tian, Thomas D. Bennett, Nigel K.H. Slater, Anthony K. Cheetham, David Fairen‐Jimenez,

Dendrimers and Hyperbranched Polymers

We report the encapsulation of the hydrophilic model molecule calcein in the Zr-based MOF UiO-66, followed by amorphization of the framework by ball-milling. We show controlled release of calcein over more than 30 days, compared with the 2 day release period from crystalline UiO-66.