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Functional classification of proteins for the prediction of cellular function from a protein-protein interaction network

2003; BioMed Central; Volume: 5; Issue: 1 Linguagem: Inglês

10.1186/gb-2003-5-1-r6

1474-760X

Christine Brun, François Chevenet, David Martin, Jérôme Wojcik, Alain Guénoche, Bernard Jacq,

Microbial Metabolic Engineering and Bioproduction

We here describe PRODISTIN, a new computational method allowing the functional clustering of proteins on the basis of protein-protein interaction data. This method, assessed biologically and statistically, enabled us to classify 11% of the Saccharomyces cerevisiae proteome into several groups, the majority of which contained proteins involved in the same biological process(es), and to predict a cellular function for many otherwise uncharacterized proteins.