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Prognostic significance of DNA cytometry for adjuvant therapy response in pancreatic cancer

2015; Wiley; Volume: 112; Issue: 1 Linguagem: Inglês

10.1002/jso.23951

1096-9098

Fritz Klein, Marcus Bahra, Anja Schirmeier, Hussein Al‐Abadi, Johann Pratschke, Uwe Pelzer, Helmut Oettle, Jana K. Striefler, Hanno Riess, Marianne Sinn,

Cancer Cells and Metastasis

Background and Objectives The continuous progress in treatment options for pancreatic adenocarcinoma has lead to a re-evaluation of prognostic markers. In this study the prognostic relevance of DNA Index and classical histopathological parameters with regard to disease-free (DFS) and overall survival (OS) was analyzed within the CONKO-001 patient population. Methods One hundred forty three fresh-frozen paraffin-embedded tissue samples of the resected tumor specimen of the CONKO-001 patient population were available for DNA index analysis to evaluate its impact on patient outcome. Results Median DFS (7.3 vs. 14.3 months; P = 0.004) and median OS (16.6 vs. 29.2 months; P = 0.011) were significantly decreased in patients with a high DNA index (>1.4). Multivariate analysis revealed both DNA index (DFS: P = 0.002; OS: P = 0.019) and tumor grading (DFS: P = 0.004; OS: P = 0.004) as individual prognostic markers for DFS and OS. The following prognostic subgroups were identified: good (low DNA Index + G1/2 tumor grading), intermediate (low DNA Index + G3 tumor grading or high DNA Index + G1/2 tumor grading), poor (high DNA Index + G3 tumor grading). Conclusion The DNA index/tumor grading constellation may serve as a helpful guide for personalized treatment recommendations for adjuvant therapy of patients with pancreatic adenocarcinoma. J. Surg. Oncol. 2015 111:66–71. © 2015 Wiley Periodicals, Inc.