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HEPATIC DRUG METABOLISM AND PROTEIN MALNUTRITION

1973; American Society for Pharmacology and Experimental Therapeutics; Volume: 186; Issue: 3 Linguagem: Inglês

10.1016/s0022-3565(25)29614-8

1521-0103

Barry H. Rumack, Jordan L. Holtzman, H. Peter Chase,

Metabolism and Genetic Disorders

The effect of chronic protein malnutrition on hepatic microsomal drug metabolism, specifically of the mixed function oxidases, has been studied. Previous studies have suggested increased hexobarbital sleeping time in malnourished rats. Macaca nemestrina monkeys were fed protein-deficient diets and developed classic features of marasmic kwashiorkor with edema and weiglmt less than 60% of controls. Total microsomal heme, phospholipids and flavin adenine dinucleotide levels, all of which are involved in microsomal drug metabolism, were significantly reduced (P in vitro to investigate possible alterations in their metabolism secondary to malnutrition. There were no differences in kinetic data comparing the control with the malnourished group when metabolism was expressed per milligram of microsomal protein or per kilogram of body weight. Alterations observed in this study, as well as the previous descriptions of altered hexobarbital sleeping time, suggest the need to reduce drug dosage in the presence of protein malnutrition.