Produção Nacional
Revisado por pares
Increase of NK Cells and Proinflammatory Monocytes Are Associated with the Clinical Improvement of Diffuse Cutaneous Leishmaniasis after Immunochemotherapy with BCG/Leishmania Antigens
2009; American Society of Tropical Medicine and Hygiene; Volume: 81; Issue: 3 Linguagem: Inglês
10.4269/ajtmh.2009.81.378
ISSN1476-1645
AutoresLedice I. A. Pereira, Miriam Leandro Dorta, Ana Joaquina Cohen Serique Pereira, Rosidete Pereira de Bastos, Milton Adriano Pelli de Oliveira, Sebastião Alves Pinto, Hélio Galdino Júnior, Wilson Mayrink, Warly Barcelos, Vicente P. C. P. Toledo, G. M. C. A. Lima, Fátima Ribeiro‐Dias,
Tópico(s)Autoimmune and Inflammatory Disorders Research
ResumoDiffuse cutaneous leishmaniasis (DCL) is characterized by disseminated lesions and the absence of a specific cellular immune response. Here, the immunochemotherapy outcome of a patient with DCL from Amazonian Brazil infected with Leishmania (Leishmania) amazonensis is presented. After several unsuccessful chemotherapy treatment regimens and many relapses, a monthly immunotherapy scheme of L. amazonensis PH8 plus L. (Viannia) braziliensis M2903 monovalent vaccines associated with Bacillus Calmette-Guerin (BCG) was established, one round of which also included an M2903 vaccine associated with intermittent antimonial treatment. Temporary healing of all lesions was achieved, although Leishmania skin tests were negative and interferon gamma was not detected in mononuclear cell cultures stimulated with Leishmania antigens. The frequencies of CD16 (+)CD56(+) NK cells (approximately 2x) and CD14 (+)CD16(+) proinflammatory monocytes (approximately 8x) increased in peripheral blood, and CD56 (+) lymphocytes were found infiltrating the lesions. An association between the increase of the frequency of innate immune system cells and the healing of lesions is shown, suggesting that this protocol of immunotherapy reduced the parasite load and activated NK cells and monocytes.
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