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The Structure of α-Helical Coiled Coils

2005; Academic Press; Linguagem: Inglês

10.1016/s0065-3233(05)70003-6

1557-8941

Andrei N. Lupas, Markus Gruber,

Protein Structure and Dynamics

alpha-Helical coiled coils are versatile protein domains, supporting a wide range of biological functions. Their fold is probably better understood than that of any other protein; indeed, uniquely among folds, their structure can be computed from a set of parametric equations. Here, we review the principles of coiled-coil structure, the determinants of their folding and stability, and the diversity of structural forms they assume.