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Effects of DTNBP1 genotype on brain development in children

2011; Wiley; Volume: 52; Issue: 12 Linguagem: Inglês

10.1111/j.1469-7610.2011.02427.x

1469-7610

Stefania Tognin, Essi Viding, Eamon McCrory, Lauren Taylor, Michael O’Donovan, Philip McGuire, Andrea Mechelli,

Neuroscience and Neuropharmacology Research

Journal of Child Psychology and PsychiatryVolume 52, Issue 12 p. 1287-1294 Effects of DTNBP1 genotype on brain development in children Stefania Tognin, Stefania Tognin Department of Psychosis Studies, Institute of Psychiatry, King's College London, LondonSearch for more papers by this authorEssi Viding, Essi Viding Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London Division of Psychology and Language Sciences, University College London, LondonSearch for more papers by this authorEamon J. McCrory, Eamon J. McCrory Division of Psychology and Language Sciences, University College London, LondonSearch for more papers by this authorLauren Taylor, Lauren Taylor Department of Psychosis Studies, Institute of Psychiatry, King's College London, LondonSearch for more papers by this authorMichael C. O'Donovan, Michael C. O'Donovan Department of Clinical Neuroscience, Division of Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, UKSearch for more papers by this authorPhilip McGuire, Philip McGuire Department of Psychosis Studies, Institute of Psychiatry, King's College London, LondonSearch for more papers by this authorAndrea Mechelli, Andrea Mechelli Department of Psychosis Studies, Institute of Psychiatry, King's College London, LondonSearch for more papers by this author Stefania Tognin, Stefania Tognin Department of Psychosis Studies, Institute of Psychiatry, King's College London, LondonSearch for more papers by this authorEssi Viding, Essi Viding Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London Division of Psychology and Language Sciences, University College London, LondonSearch for more papers by this authorEamon J. McCrory, Eamon J. McCrory Division of Psychology and Language Sciences, University College London, LondonSearch for more papers by this authorLauren Taylor, Lauren Taylor Department of Psychosis Studies, Institute of Psychiatry, King's College London, LondonSearch for more papers by this authorMichael C. O'Donovan, Michael C. O'Donovan Department of Clinical Neuroscience, Division of Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, UKSearch for more papers by this authorPhilip McGuire, Philip McGuire Department of Psychosis Studies, Institute of Psychiatry, King's College London, LondonSearch for more papers by this authorAndrea Mechelli, Andrea Mechelli Department of Psychosis Studies, Institute of Psychiatry, King's College London, LondonSearch for more papers by this author First published: 03 June 2011 https://doi.org/10.1111/j.1469-7610.2011.02427.xCitations: 15 Conflict of interest statement: No conflicts declared. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Background: Schizophrenia is a neurodevelopmental disorder, and risk genes are thought to act through disruption of brain development. Several genetic studies have identified dystrobrevin-binding protein 1 (DTNBP1, also known as dysbindin) as a potential susceptibility gene for schizophrenia, but its impact on brain development is poorly understood. The present investigation examined for the first time the effects of DTNBP1 on brain structure in children. Our hypothesis was that a genetic variation in DTNBP1 (i.e., the single nucleotide polymorphism rs2619538) would be associated with differences in both gray and white matter brain regions previously implicated in schizophrenia. Methods: Magnetic resonance imaging and voxel-based morphometry were used to examine brain structure in 52 male children aged between 10 and 12 years. Statistical inferences on the effects of DTNBP1 genotype on gray and white matter volume (GMV and WMV) were made at p < .05 after family-wise error correction for multiple comparisons across the whole brain. Results: Individuals homozygous for the schizophrenia high-risk allele (AA) compared with those homozygous for the low-risk allele (TT) expressed reduced GMV in the left anterior cingulate gyrus and reduced WMV in the left medial frontal area. 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