The cellular origin and malignant transformation of Waldenström macroglobulinemia
2015; Elsevier BV; Volume: 125; Issue: 15 Linguagem: Inglês
10.1182/blood-2014-09-602565
ISSN1528-0020
AutoresBruno Paiva, Luís A. Corchete, María‐Belén Vidriales, Ramón García‐Sánz, José J. Pérez, Irene Aires‐Mejía, María-Luz Sánchez, Paloma Bárcena, Diego Alignani, Cristina Jiménez, María Eugenia Sarasquete, María‐Victoria Mateos, Enrique M. Ocio, Noemí Puig, Fernando Escalante, José‐Ángel Hernández‐Rivas, Rebeca Cuello, Alfonso García de Coca, Magdalena Sierra, Maria-Carmen Montes, Tomás José González‐López, Josefina Galende, Abelardo Bárez, José María Alonso, Emilia Pardal, Alberto Órfão, Norma C. Gutiérrez, Jesús F. San Miguel,
Tópico(s)Immunodeficiency and Autoimmune Disorders
ResumoKey Points Benign (ie, IgM MGUS and smoldering WM) clonal B cells already harbor the phenotypic and molecular signatures of the malignant WM clone. Multistep transformation from benign (ie, IgM MGUS and smoldering WM) to malignant WM may require specific copy number abnormalities.
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