From white spots to stem cells: the role of the Kit receptor in mammalian development
1993; Elsevier BV; Volume: 9; Issue: 8 Linguagem: Inglês
10.1016/0168-9525(93)90015-a
ISSN1362-4555
Autores Tópico(s)Fibroblast Growth Factor Research
ResumoThe Kit tyrosine kinase membrane receptor is essential for melanogenesis, gametogenesis and hematopoiesis during embryonic development and postnatal life. This review summarizes the genetic evidence implicating Kit and its ligand, Steel factor, in the control of stem cell proliferation, migration and survival, with emphasis on mutations in the human and mouse genes.
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