The Mechanisms of Vesicle Budding and Fusion
2004; Cell Press; Volume: 116; Issue: 2 Linguagem: Inglês
10.1016/s0092-8674(03)01079-1
ISSN1097-4172
AutoresJuan S. Bonifacino, Benjamin S. Glick,
Tópico(s)Lipid Membrane Structure and Behavior
ResumoAbstract Genetic and biochemical analyses of the secretory pathway have produced a detailed picture of the molecular mechanisms involved in selective cargo transport between organelles. This transport occurs by means of vesicular intermediates that bud from a donor compartment and fuse with an acceptor compartment. Vesicle budding and cargo selection are mediated by protein coats, while vesicle targeting and fusion depend on a machinery that includes the SNARE proteins. Precise regulation of these two aspects of vesicular transport ensures efficient cargo transfer while preserving organelle identity.
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