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β-adrenergic receptor induction in HeLa cells: Synergistic effect of 5-azacytidine and butyrate

1982; Elsevier BV; Volume: 108; Issue: 4 Linguagem: Inglês

10.1016/s0006-291x(82)80067-3

1090-2104

Saleem Jahangeer, Richard M. Elliott, Richard C. Henneberry,

Neuroscience and Neuropharmacology Research

We have described the induction of β-adrenergic receptors by butyrate in HeLa cells. Here we report preliminary results showing that β-adrenergic receptors can be induced to comparable levels by the nucleoside analogue 5-azacytidine. More importantly, sequential exposure to the two compounds has a strong synergistic effect; 5-azacytidine treatment for 24 hr followed by 24 hr exposure to butyrate results in receptor induction to levels 2 to 3 times greater than the sum of those found with butyrate and 5-azacytidine alone. Our results imply that induction of β-adrenergic receptors in HeLa by butyrate and 5-azacytidine may involve separate mechanisms.