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Teratogens associated with congenital contractures in humans and in animals

1982; Wiley; Volume: 25; Issue: 2 Linguagem: Inglês

10.1002/tera.1420250207

2472-1727

Judith G. Hall, Susan D. Reed,

Child and Adolescent Health

Abstract An evaluation of over 350 patients in a study of congenital contractures of the joints (arthrogryposis) included a review of family, pregnancy, and delivery histories for teratogenic exposures. Fifteen out of the total 350 patients studied had a possible teratogenic exposure: an infectious agent (viral or bacterial), maternal drug or toxin ingestion, chronic maternal neurologic or muscular illness, or a direct physical insult such as a structural uterine anomaly. Literature was reviewed for all human and animal cases reported with congenital contractures of the joints with an associated teratogenic insult. Those findings are discussed here.