Neuronal ATP receptors and their mechanism of action
1993; Elsevier BV; Volume: 14; Issue: 2 Linguagem: Inglês
10.1016/0165-6147(93)90030-n
ISSN1873-3735
AutoresPéter Illés, Wolfgang Nörenberg,
Tópico(s)Neuroscience and Neuropharmacology Research
ResumoATP stores and supplies energy in neurons, but it also acts as a transmitter molecule. ATP activates a class of membrane receptors termed P2 purinoceptors. Based on the potencies of structural analogues of ATP, P2 purinoceptors in non-neuronal tissues were classified by classic pharmacological methods into two subtypes, P2x and P2y. Peter Illes and Wolfgang Nörenberg report that electrophysiological investigations indicate the presence of P2y-like purinoceptors on neurons. They describe two alternative ionic transduction mechanisms that may be activated by this receptor family.
Referência(s)