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Myocardial Contrast Echocardiography Demonstrates That Collateral Flow Can Preserve Myocardial Function Beyond a Chronically Occluded Coronary Artery

1996; Elsevier BV; Volume: 78; Issue: 8 Linguagem: Inglês

10.1016/s0002-9149(96)00478-x

1879-1913

Sarah M. Vernon, Gustavo Camarano, Sanjiv Kaul, Ian J. Sarembock, Lawrence W. Gimple, Eric R. Powers, Michael Ragosta,

Advanced MRI Techniques and Applications

Traditionally, the clinical assessment of collaterals has been performed using coronary angiography,[ 1 Gorlin R. Coronary collaterals. Major Probl Intern Med. 1976; 11: 59-70 PubMed Google Scholar , 2 Khaja F Sabbah HN Brymer JF Stein PD Influence of coronary collaterals on left ventricular function in patients undergoing coronary angioplasty. Am Heart J. 1988; 116: 1174-1180 Abstract Full Text PDF PubMed Scopus (22) Google Scholar , 3 Rentrop KP Feit F Sherman W Stecy P Hosat S Cohen M Rey M Ambrose J Nachamie M Schwartz W Cole W Perdoncin R Thornton JC Late thrombolytic therapy preserves left ventricular function in patients with collateralized total coronary occlusion: primary end point findings of the Second Mount Sinai-New York University Reperfusion Trial. J Am Coll Cardiol. 1989; 14: 58-64 Abstract Full Text PDF PubMed Scopus (97) Google Scholar , 4 Saito Y Yasuno M Ishida M Suzuki K Matoba Y Emura M Takahashi M Importance of coronary collaterals for restoration of left ventricular function after intracoronary thrombolysis. Am J Cardiol. 1985; 55: 1259-1263 Abstract Full Text PDF PubMed Scopus (78) Google Scholar , 5 Cohen M Rentrop KP Limitation of myocardial ischemia by collateral circulation during sudden controlled coronary artery occlusion in human subjects: a prospective study. Circulation. 1986; 74: 469-476 Crossref PubMed Scopus (396) Google Scholar ]which does not provide information regarding myocardial tissue perfusion. Myocardial contrast echocardiography, which defines the spatial extent and magnitude of tissue perfusion, has been previously shown by us to be useful for assessing the functional significance of collateral flow in patients within 5 weeks of acute myocardial infarction.[ 6 Sabia PJ Powers ER Jayaweera AR Ragosta M Kaul S Functional significance of collateral blood flow in patients with recent acute myocardial infarction. Circulation. 1992; 85: 2080-2089 Crossref PubMed Scopus (206) Google Scholar ]The aim of the current study was to define the relation between angiographic collaterals, microvascular perfusion, and regional function within the infarct bed in patients with remote myocardial infarction and chronically occluded coronary arteries.