Rapid access to uronic acid-based mimetics of Kdn2en from d-glucurono-6,3-lactone
2000; Elsevier BV; Volume: 328; Issue: 4 Linguagem: Inglês
10.1016/s0008-6215(00)00228-7
ISSN1873-426X
AutoresPas Florio, Robin J. Thomson, Mark von Itzstein,
Tópico(s)Chemical Synthesis and Analysis
ResumoA concise route to novel mimetics of Kdn2en, based on Δ4-uronic acids, from d-glucurono-6,3-lactone is presented. Uronic acid-based mimetics in which an aliphatic ether (O-glycoside), a thioether (S-glycoside), or acetamide takes the place of the natural C-6 glycerol sidechain of the sialic acid were synthesized from the key intermediate, methyl 2,3,4-tri-O-acetyl-α-d-glucopyranosyluronate bromide.
Referência(s)