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BIBTEX RIS

STUDY OF NEW COMPLEXES OF CHROMIUM(III), COBALT(II), NICKEL(II), COPPER(II), AND ZINC(II) WITH GUANIDINOACETIC ACID, THE PRECURSOR OF CREATINE

2001; Taylor & Francis; Volume: 31; Issue: 5 Linguagem: Inglês

10.1081/sim-100104857

ISSN

1532-2440

Autores

Jussara Lopes de Miranda, Judith Felcman,

Tópico(s)

Computational Drug Discovery Methods

Resumo

Abstract Guanidinoacetic acid (H2Gaa), the essential precursor of creatine, plays an important role in our organism. However, H2Gaa interaction with metal ions has not yet been studied. We have previously studied H2Gaa complexation with some metallic ions in solution. In this study, Cr(III), Co(II), Ni(II), Cu(II) and Zn(II) complexes of H 2Gaa were synthesized and characterized (C, H, N, thermogravimetric analyses, infrared spectroscopy). Electron paramagnetic resonance and ultraviolet spectroscopy were also used but in aqueous solutions at 25 °C. In all of the cases the coordinating atoms were the alpha-nitrogen and oxygen atoms. The most probable geometry of each of the complexes is cis-square-planar in Cu(HGaa)2, tetrahedral in Zn(H2Gaa)NO3Cl and octahedral in Cr(HGaa)3, CoH2Gaa(HGaa)2 and NiH2Gaa(HGaa)2. ACKNOWLEDGMENTS The authors wish to express their thanks to Dr. Douglas Wagner Franco and Mario Sergio Schultz of the Chemistry Department, Universidade de São Paulo (USP), São Carlos, Brazil, for measuring the X-band EPR spectra (FAPESP process n° 92/3515-3).

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