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Multiarchitectonic and stereotactic atlas of the human thalamus

1997; Wiley; Volume: 387; Issue: 4 Linguagem: Inglês

10.1002/(sici)1096-9861(19971103)387

1096-9861

Anne Morel, Michel Magnin, Daniel Jeanmonod,

Genetic Neurodegenerative Diseases

Journal of Comparative NeurologyVolume 387, Issue 4 p. 588-630 Multiarchitectonic and stereotactic atlas of the human thalamus Anne Morel, Corresponding Author Anne Morel [email protected] Functional Neurosurgery, Neurosurgery Clinic, University Hospital Zurich, 8091 Zurich, SwitzerlandFunctional Neurosurgery, Neurosurgery Clinic, University Hospital Zurich, 8091 Zurich, SwitzerlandSearch for more papers by this authorMichel Magnin, Michel Magnin Functional Neurosurgery, Neurosurgery Clinic, University Hospital Zurich, 8091 Zurich, SwitzerlandSearch for more papers by this authorDaniel Jeanmonod, Daniel Jeanmonod Functional Neurosurgery, Neurosurgery Clinic, University Hospital Zurich, 8091 Zurich, SwitzerlandSearch for more papers by this author Anne Morel, Corresponding Author Anne Morel [email protected] Functional Neurosurgery, Neurosurgery Clinic, University Hospital Zurich, 8091 Zurich, SwitzerlandFunctional Neurosurgery, Neurosurgery Clinic, University Hospital Zurich, 8091 Zurich, SwitzerlandSearch for more papers by this authorMichel Magnin, Michel Magnin Functional Neurosurgery, Neurosurgery Clinic, University Hospital Zurich, 8091 Zurich, SwitzerlandSearch for more papers by this authorDaniel Jeanmonod, Daniel Jeanmonod Functional Neurosurgery, Neurosurgery Clinic, University Hospital Zurich, 8091 Zurich, SwitzerlandSearch for more papers by this author First published: 06 December 1998 https://doi.org/10.1002/(SICI)1096-9861(19971103)387:4 3.0.CO;2-ZCitations: 414AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract To improve anatomical definition and stereotactic precision of thalamic targets in neurosurgical treatments of chronic functional disorders, a new atlas of the human thalamus has been developed. This atlas is based on multiarchitectonic parcellation in sections parallel or perpendicular to the standard intercommissural reference plane. The calcium-binding proteins parvalbumin (PV), calbindin D-28K (CB), and calretinin (CR) were used as neurochemical markers to further characterize thalamic nuclei and delimit subterritories of functional significance for stereotactic explorations. Their overall distribution reveals a subcompartmentalization of thalamic nuclei into several groups. Predominant PV immunostaining characterizes primary somatosensory, visual and auditory nuclei, the ventral lateral posterior nucleus, reticular nucleus (R), and to a lesser degree also, lateral part of the centre médian nucleus, and anterior, lateral, and inferior divisions of the pulvinar complex. In contrast, CB immunoreactivity is prevalent in medial thalamic nuclei (intralaminar and midline), the posterior complex, ventral posterior inferior nucleus, the ventral lateral anterior nucleus, ventral anterior, and ventral medial nuclei. The complementary distributions of PV and CB appear to correlate with distinct lemniscal and spinothalamic somatosensory pathways and to cerebellar and pallidal motor territories, respectively. Calretinin, while overlapping with CB in medial thalamic territories, is also expressed in R and limbic associated anterior group nuclei that contain little or no CB. 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