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Erysothrine, an alkaloid extracted from flowers of Erythrina mulungu Mart. ex Benth: Evaluating its anticonvulsant and anxiolytic potential

2012; Elsevier BV; Volume: 23; Issue: 3 Linguagem: Inglês

10.1016/j.yebeh.2012.01.003

1525-5069

Daiane Santos Rosa, Silmara Aparecida Faggion, Amanda Salomão Gavin, Maicon Anderson de Souza, Helene Fachim, Wagner Ferreira dos Santos, Ana Maria Soares Pereira, Alexandra Olímpio Siqueira Cunha, Renê Oliveira Beleboni,

Plant chemical constituents analysis

In this study, we isolated the alkaloid erysothrine from the hydroalcoholic extract of flowers from E. mulungu and screened for its anticonvulsant and anxiolytic actions based on neuroethological and neurochemical experiments. Our results showed that the administration of erysothrine inhibited seizures evoked by bicuculline, PTZ, NMDA and most remarkably, kainic acid. Also, erysothrine induced an increase in the number of entries but not in the time spent in the open arms of the EPM. However, we did not notice any alterations in the light-dark choice or in the open-field tests. In preliminary neurochemistry tests, we also showed that erysothrine (0.001-10 μg/mL) did not alter the GABA or glutamate synaptossomal uptake and binding. Altogether, our results describe an alkaloid with anticonvulsant activity and mild anxiolytic activity that might be considered well tolerated as it does not alter the general behavior of the animals in the used doses.