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Whither or Wither Microbicides?

2008; American Association for the Advancement of Science; Volume: 321; Issue: 5888 Linguagem: Inglês

10.1126/science.1160355

1095-9203

Robert M. Grant, Dean H. Hamer, Thomas J. Hope, Rowena Johnston, Joep M. A. Lange, Michael M. Lederman, Judy Lieberman, Christopher J. Miller, John P. Moore, Donald E. Mosier, Douglas D. Richman, Robert T. Schooley, Marty S. Springer, Ronald S. Veazey, Mark A. Wainberg,

HIV/AIDS Research and Interventions

After disappointing results from all efficacy trials conducted to date, the field of microbicides research now faces substantial challenges. Poor coordination among interested parties and the choice of nonvalidated scientific targets for phase III studies have hampered progress and created mistrust about the use of microbicides as a method to prevent HIV-1 sexual transmission. Although new promising strategies are available, there will need to be serious reappraisals of how decisions are made to advance the next generations of candidates into clinical trials, and the use of appropriate animal models in this process will be critical.