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Ursodeoxycholic acid therapy in pregnant women with cholestasis

1996; Elsevier BV; Volume: 52; Issue: 2 Linguagem: Inglês

10.1016/0020-7292(95)02528-6

1879-3479

A Diaferia, P. L. Nicastri, Massimo Tartagni, P Loizzi, C. Iacovizzi, Alfredo Di Leo,

Liver Diseases and Immunity

International Journal of Gynecology & ObstetricsVolume 52, Issue 2 p. 133-140 Articles Ursodeoxycholic acid therapy in pregnant women with cholestasis A. Diaferia, A. Diaferia 2nd Department of Obstetrics and Gynecology, University of Bari, Bari, ItalySearch for more papers by this authorP.L. Nicastri, P.L. Nicastri 2nd Department of Obstetrics and Gynecology, University of Bari, Bari, ItalySearch for more papers by this authorM. Tartagni, M. Tartagni 2nd Department of Obstetrics and Gynecology, University of Bari, Bari, ItalySearch for more papers by this authorP. Loizzi, P. Loizzi 2nd Department of Obstetrics and Gynecology, University of Bari, Bari, ItalySearch for more papers by this authorC. Iacovizzi, C. Iacovizzi 2nd Department of Obstetrics and Gynecology, University of Bari, Bari, ItalySearch for more papers by this authorA. Di Leo, A. Di Leo Biochemistry Laboratory IRCCS 'S. de Bellis', Castellana Grotte (Ba, ItalySearch for more papers by this author A. Diaferia, A. Diaferia 2nd Department of Obstetrics and Gynecology, University of Bari, Bari, ItalySearch for more papers by this authorP.L. Nicastri, P.L. Nicastri 2nd Department of Obstetrics and Gynecology, University of Bari, Bari, ItalySearch for more papers by this authorM. Tartagni, M. Tartagni 2nd Department of Obstetrics and Gynecology, University of Bari, Bari, ItalySearch for more papers by this authorP. Loizzi, P. Loizzi 2nd Department of Obstetrics and Gynecology, University of Bari, Bari, ItalySearch for more papers by this authorC. Iacovizzi, C. Iacovizzi 2nd Department of Obstetrics and Gynecology, University of Bari, Bari, ItalySearch for more papers by this authorA. Di Leo, A. Di Leo Biochemistry Laboratory IRCCS 'S. de Bellis', Castellana Grotte (Ba, ItalySearch for more papers by this author First published: February 1996 https://doi.org/10.1016/0020-7292(95)02528-6Citations: 62 Corresponding author, Via Petraglione 24 sc. B, 70124 Bari, Italy, Tel.: +39 80 5017839. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Objective: To test the efficacy and safety of ursodeoxycholic acid (UDCA) in the treatment of intrahepatic cholestasis of pregnancy (ICP) by a randomized, double-blind, placebo-controlled trial. Method: Eight patients with pruritus and abnormal liver function tests received 600 mg/day of UDCA in two doses for 20 days, compared with a control group of eight patients who received placebo for 20 days. Results: No adverse reactions were detected in any patient. During UDCA therapy a statistically significant improvement in pruritus, serum bile salt levels, serum glutamic pyruvic transaminase, alkaline phosphatase, gamma-glutamyl transpeptidase and total and direct bilirubin was observed. Only two patients treated with UDCA underwent cesarean sections due to reasons unrelated to the therapeutic trial. All newborns had an Apgar score >7 and normal postnatal growth. Conclusion: Although the number of patients in this study was very small, we suggest that UDCA treatment has a role in improving clinical and biochemical results in ICP. Citing Literature Volume52, Issue2February 1996Pages 133-140 RelatedInformation