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Effect of Tumor Necrosis Factor-α Gene Polymorphism on Peri-Implant Bone Loss Following Prosthetic Reconstruction

2007; Lippincott Williams & Wilkins; Volume: 16; Issue: 1 Linguagem: Inglês

10.1097/id.0b013e31803277c1

1538-2982

Patrícia Ramos Cury, Júlio César Joly, Nívea Maria de Freitas, Wilson Roberto Sendyk, Fábio Daumas Nunes, Ney Soares de Araújo,

Orthopedic Infections and Treatments

Purpose: The present study investigates the association between a specific polymorphism in the tumor necrosis factor (TNF)-α gene, consisting of allele 2 of TNF-α−308, and peri-implant bone loss following prosthetic reconstruction. Materials and Methods: This case-control study included 36 patients (20 women, 16 men; mean age 46 years) who had used implant-supported prostheses for a minimum of 6 months and a maximum of 31 months. The patients were nonsmoking, white Caucasian Brazilians, in good general health, and were not receiving medication. In the case group, patients exhibited 1 or more implants with a diagnosis of peri-implant bone loss following prosthetic reconstruction; control patients had 1 or more healthy implants. Results: Polymorphism in the TNF-α gene, allele 2 of TNF-α−308, was not associated with an increased risk for peri-implant bone loss following prosthetic reconstruction (P = 0.19; χ2 = 1.71; df = 1), although 21.1% of the subjects carried allele in the control group 2, and 41.2% carried allele 2 in the case group. Conclusions: Polymorphism in allele 2 of the TNF-α−308 gene is not associated with an increased risk for peri-implant bone loss following prosthetic reconstruction. However, further studies based on a greater number of patients are necessary.