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The up-and-down method for the determination of nociceptive thresholds in rats

1984; Elsevier BV; Volume: 21; Issue: 1 Linguagem: Inglês

10.1016/0091-3057(84)90142-4

1873-5177

Ann D. Crocker, Roger W. Russell,

Stress Responses and Cortisol

The up-and-down method applied to the jump-flinch technique provided estimates of shock thresholds for jump and flinch with high statistical efficiency and a much reduced amount of experimentation compared with traditional methods. Reproducible results were obtained after repeated testing and flinch and jump thresholds were significantly increased by treatment with morphine or oxotremorine.