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Immunodeficiency in HIV-2 infection

1990; Lippincott Williams & Wilkins; Volume: 4; Issue: 12 Linguagem: Inglês

10.1097/00002030-199012000-00013

1473-5571

Ida Maria Lisse, Anja Poulsen, Peter Aaby, Michel Normark, Birgit Kvinesdal, Francisco Dias, KåRre Molbak, Kim Knudsen,

HIV/AIDS Research and Interventions

In a community study in Guinea-Bissau, West Africa, 47 HIV-2-seropositive cases and 87 matched controls were evaluated immunologically using immuno-alkaline phosphatase linked to avidin-biotin complex for the assessment of CD4 and CD8 status. HIV-2-seropositive individuals had significantly lower total numbers of CD4 cells and CD4/CD8 ratios, 38% having a total number of CD4 cells ≤0.5 × 109/l and 36% having a CD4/CD8 ratio ≤0.8. Total numbers of CD4 cells ≤0.5 × 109/l or CD4/CD8 ratio ≤0.8 were found in 53% of the HIV-2 seropositives compared with 11% among controls [odds ratio (OR) = 7.3; 95% confidence interval (CD: 3.1–17.1]. Lymphadenopathy was significantly more frequent among HIV-2 seropositives than among controls (OR = 3.4; 95% Cl: 1.5–7.6). HIV-2 seropositives with lymphadenopathy had significantly fewer lymphocytes (P = 0.008) and lower total CD4 (P = 0.029) and total CD8 number (P = 0.011) than HIV-2 seropositives without lymphadenopathy. This study indicates that HIV-2 has a significant immunosuppressive effect.