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RBC T activation and hemolysis: implications for pediatric transfusion management

2000; Wiley; Volume: 40; Issue: 7 Linguagem: Inglês

10.1046/j.1537-2995.2000.40070801.x

1537-2995

Kendall P. Crookston, Alex P. Reiner, Laurence J.N. Cooper, R. A. Sacher, M.A. Blajchman, Nancy M. Heddle,

Erythrocyte Function and Pathophysiology

TransfusionVolume 40, Issue 7 p. 801-812 RBC T activation and hemolysis: implications for pediatric transfusion management K.P. Crookston, K.P. Crookston From the Departments of Medicine, Pediatrics, and Laboratory Medicine, University of Washington, the Fred Hutchinson Cancer Research Center, and the Puget Sound Blood Center, Seattle, Washington; the Department of Laboratory Medicine, Georgetown University Medical Center, Washington, DC; and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.Search for more papers by this authorA.P. Reiner, A.P. Reiner From the Departments of Medicine, Pediatrics, and Laboratory Medicine, University of Washington, the Fred Hutchinson Cancer Research Center, and the Puget Sound Blood Center, Seattle, Washington; the Department of Laboratory Medicine, Georgetown University Medical Center, Washington, DC; and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.Search for more papers by this authorL.J.N. Cooper, L.J.N. Cooper From the Departments of Medicine, Pediatrics, and Laboratory Medicine, University of Washington, the Fred Hutchinson Cancer Research Center, and the Puget Sound Blood Center, Seattle, Washington; the Department of Laboratory Medicine, Georgetown University Medical Center, Washington, DC; and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.Search for more papers by this authorR.A. Sacher, R.A. Sacher From the Departments of Medicine, Pediatrics, and Laboratory Medicine, University of Washington, the Fred Hutchinson Cancer Research Center, and the Puget Sound Blood Center, Seattle, Washington; the Department of Laboratory Medicine, Georgetown University Medical Center, Washington, DC; and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.Search for more papers by this authorM.A. Blajchman, M.A. Blajchman From the Departments of Medicine, Pediatrics, and Laboratory Medicine, University of Washington, the Fred Hutchinson Cancer Research Center, and the Puget Sound Blood Center, Seattle, Washington; the Department of Laboratory Medicine, Georgetown University Medical Center, Washington, DC; and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.Search for more papers by this authorN.M. Heddle, N.M. Heddle From the Departments of Medicine, Pediatrics, and Laboratory Medicine, University of Washington, the Fred Hutchinson Cancer Research Center, and the Puget Sound Blood Center, Seattle, Washington; the Department of Laboratory Medicine, Georgetown University Medical Center, Washington, DC; and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.Search for more papers by this author K.P. Crookston, K.P. Crookston From the Departments of Medicine, Pediatrics, and Laboratory Medicine, University of Washington, the Fred Hutchinson Cancer Research Center, and the Puget Sound Blood Center, Seattle, Washington; the Department of Laboratory Medicine, Georgetown University Medical Center, Washington, DC; and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.Search for more papers by this authorA.P. Reiner, A.P. Reiner From the Departments of Medicine, Pediatrics, and Laboratory Medicine, University of Washington, the Fred Hutchinson Cancer Research Center, and the Puget Sound Blood Center, Seattle, Washington; the Department of Laboratory Medicine, Georgetown University Medical Center, Washington, DC; and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.Search for more papers by this authorL.J.N. Cooper, L.J.N. Cooper From the Departments of Medicine, Pediatrics, and Laboratory Medicine, University of Washington, the Fred Hutchinson Cancer Research Center, and the Puget Sound Blood Center, Seattle, Washington; the Department of Laboratory Medicine, Georgetown University Medical Center, Washington, DC; and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.Search for more papers by this authorR.A. Sacher, R.A. Sacher From the Departments of Medicine, Pediatrics, and Laboratory Medicine, University of Washington, the Fred Hutchinson Cancer Research Center, and the Puget Sound Blood Center, Seattle, Washington; the Department of Laboratory Medicine, Georgetown University Medical Center, Washington, DC; and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.Search for more papers by this authorM.A. Blajchman, M.A. Blajchman From the Departments of Medicine, Pediatrics, and Laboratory Medicine, University of Washington, the Fred Hutchinson Cancer Research Center, and the Puget Sound Blood Center, Seattle, Washington; the Department of Laboratory Medicine, Georgetown University Medical Center, Washington, DC; and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.Search for more papers by this authorN.M. Heddle, N.M. Heddle From the Departments of Medicine, Pediatrics, and Laboratory Medicine, University of Washington, the Fred Hutchinson Cancer Research Center, and the Puget Sound Blood Center, Seattle, Washington; the Department of Laboratory Medicine, Georgetown University Medical Center, Washington, DC; and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.Search for more papers by this author First published: 24 April 2002 https://doi.org/10.1046/j.1537-2995.2000.40070801.xCitations: 55 Address reprint requests to: Kendall Crookston, MD, PhD, Department of Pathology, University of New Mexico, BMSB-335, 915 Camino de Salud NE, Albuquerque, NM 87131-5301; e-mail: [email protected]. Supported in part by Grant #CA09351 from the National Cancer Institute (LJNC). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL REFERENCES 1 Poulsen MPE. [ Polyagglutinability and T transformation] (Engl summary). (dissertation). Copenhagen, Denmark: University of Copenhagen, 1961. 186 p. 2 Williams RA, Brown EF, Hurst D, Franklin LC. Transfusion of infants with activation of erythrocyte T antigen. J Pediatr 1989; 115: 949– 53. 3 Lenz G, Goes U, Baron D, et al. Red blood cell T-activation and hemolysis in surgical intensive care patients with severe infections. Blut 1987; 54: 89– 96. 4 Novak RW, Abbott AE Jr, Klein RL. T-cryptantigen determination affects mortality in necrotizing enterocolitis. Surg Gynecol Obstet 1993; 176: 368– 70. 5 Novak RW. The pathobiology of red cell cryptantigen exposure. Pediatr Pathol 1990; 10: 867– 75. 6 Engelfriet CP, Reesink HW, Strauss RG, et al. Blood transfusion in premature or young infants with polyagglutination and activation of the T antigen. Vox Sang 1999; 76: 128– 32. 7 Kleihauer E, Braun H, Betke K. [Demonstration of fetal hemoglobin in the red cells of peripheral blood smears]. Klin Wochenschr 1957; 35: 637– 8. 8 Hübener G. [Investigation of isoagglutination, with special consideration of apparent deviations from the blood grouping scheme]. Z Immunitatsforsch 1926; 45: 223– 48. 9 Thomsen O. [A proliferative agent that changes the isoagglutination behavior of red cells: a previously unknown source of error]. Z Immunitatsf 1927; 52: 85– 107. 10 Friedenreich V. Investigations into the Thomsen hemagglutination phenomena. Acta Path Microbiol Scand 1928; 5: 59– 101. 11 Friedenreich V. The Thomsen hemagglutination phenomenon. Production of a specific receptor quality in red corpuscles by bacterial activity (dissertation). Copenhagen, Denmark: University of Copenhagen, 1930, 138 p. 12 Vaith P, Uhlenbruck G. The Thomsen agglutination phenomenon: a discovery revisited 50 years later. Z Immunitatsforsch Allerg Klin Immunol 1978; 154: 1– 15. 13 Reepmaker J. The relation between polyagglutinability of erythrocytes in vivo and the Hübener-Thomsen-Friedenreich phenomenon. J Clin Pathol 1952; 5: 266– 70. 14 Chorpenning FW, Hayes JC. Occurrence of the Thomsen-Friedenreich phenomenon in vivo. Vox Sang 1959; 4: 210– 24. 15 Poulsen PE. Experimentally produced "polyagglutinability" (T-transformation of erthrocytes in vivo) in guinea pigs infected with pneumococci. Nature 1954; 173: 82– 3. 16 Poulsen PE. Haemolytic anaemia produced experimentally in the guinea pig by T-transformation of the erthrocytes in vivo with purified concentrated enzyme. Nature 1954; 174: 929– 30. 17 Chu CM. Enzymic action of viruses and bacterial products on human red cells. Nature 1948; 161: 606– 7. 18 Doinel C, Andreu G, Cartron JP, et al. Tk polyagglutination produced in vitro by an endo-beta-galactosidase. Vox Sang 1980; 38: 94– 8. 19 Sondag-Thull D, Levene NA, Levene C, et al. Characterization of a neuraminidase from Corynebacterium aquaticum responsible for Th polyagglutination. Vox Sang 1989; 57: 193– 8. 20 Wahl CM, Herman JH, Shirey RS, et al. Th activation of maternal and cord blood. Transfusion 1989; 29: 635– 7. 21 Bird GW, Wingham J, Beck ML, et al. Th, a "new" form of erythrocyte polyagglutination. Lancet 1978; 1: 1215– 6. 22 Bird GW, Wingham J, Seger R, Kenny AB. Tx, a "new" red cell cryptantigen exposed by pneumococcal enzymes. Rev Fr Transfus Immunohematol 1982; 25: 215– 6. 23 Levene C, Levene NA, Buskila D, Manny N. Red cell polyagglutination. Transfus Med Rev 1988; 2: 176– 85. 24 Bird GWG. Lectins and red cell polyagglutinability: history, comments, and recent developments. In: ML Beck, WJ Judd, eds. Polyagglutination, a technical workshop. Washington: American Association of Blood Banks, 1980: 71– 90. 25 Judd WJ. Polyaggulatination. Immunohematology 1992; 8: 58– 69. 26 PD Issitt, D Anstee, eds. Applied blood group serology. 4th ed. Durham, NC: Montgomery Scientific Publications, 1998. 27 Bird GW. Anti-T in peanuts. Vox Sang 1964; 9: 748– 9. 28 Buskila D, Levene C, Bird GW, Levene NA. Polyagglutin-ation in hospitalized patients: a prospective study. Vox Sang 1987; 52: 99– 102. 29 Novak RW. Bacterial-induced RBC alterations complicating necrotizing enterocolitis. Am J Dis Child 1984; 138: 183– 5. 30 Klein RL, Novak RW, Novak PE. T-cryptantigen exposure in neonatal necrotizing enterocolitis. J Pediatr Surg 1986; 21: 1155– 8. 31 Seger R, Joller P, Bird GW, et al. Necrotising enterocolitis and neuraminidase-producing bacteria. Helv Paediatr Acta 1980; 35: 121– 8. 32 Mizusawa Y, Pitcher LA, Burke JR, et al. Survey of haemolytic-uraemic syndrome in Queensland 1979-1995. Med J Aust 1996; 165: 188– 91. 33 Gaffney JC, Sachs H. Polyagglutinability of human red blood cells. J Pathol Bacteriol 1943; 55: 489– 92. 34 Rawlinson VI, Stratton F. Incidence of T activation in a hospital population. Vox Sang 1984; 46: 306– 17. 35 Springer GF, Tegtmeyer H. Origin of anti-Thomsen-Friedenreich (T) and Tn agglutinins in man and in White Leghorn chicks. Br J Haematol 1981; 47: 453– 60. 36 Kim YD, Prakash U, Weber GF, Hargie M. Nature of human serum blood group T antibodies. Immunol Commun 1979; 8: 397– 406. 37 Moores P, Pudifin D, Patel PL. Severe hemolytic anemia in an adult associated with anti-T. Transfusion 1975; 15: 329– 33. 38 McTaggart SJ, Burke JR. Streptococcus pneumoniae-induced haemolytic uraemic syndrome. J Paediatr Child Health 1998; 34: 192– 5. 39 Issitt PD, Issitt CH, Moulds J, Berman HJ. Some observations on the T, Tn and Sda antigens and the antibodies that define them. Transfusion 1972; 12: 217– 21. 40 Van Loghem JJ Jr, Van Der Hart M, Land ME. Polyagglutinability of red cells as a cause of severe haemolytic transfusion reaction. Vox Sang 1955; 5: 125– 8. 41 Mupanemunda RH, Kenyon CF, Inwood MJ, Leigh K. Bacterial-induced activation of erythrocyte T-antigen complicating necrotising enterocolitis: a case report. Eur J Pediatr 1993; 152: 325– 6. 42 Judd WJ, Oberman HA, Flynn S. Fatal intravascular hemolysis associated with T-polyagglutination. Transfusion 1982; 22: 345– 6. 43 Levene C, Sela R, Blat J, et al. Intravascular hemolysis and renal failure in a patient with T polyagglutination. Transfusion 1986; 26: 243– 5. 44 De Muralt PG, HŠssig R, De Reynier H. [A case of transient RBC polyagglutination in a patient of blood group A]. Rev Hematol 1952; 7: 372– 80. 45 Freedman J. False-positive antiglobulin tests in healthy subjects and in hospital patients. J Clin Pathol 1979; 32: 1014– 8. 46 Friedenreich V, Munck J. Intravital effects of "transformed" blood corpuscles in guinea-pigs. Acta Path Microbiol Scand 1930; 7: 134– 45. 47 Stewart WB, Petenyi CW, Rose HM. The survival time of canine erythrocytes modified by influenza virus. Blood 1955; 10: 228– 34. 48 Uhlenbruck G, Pardoe GI, Bird GW. On the specificity of lectins with a broad agglutination spectrum. II. Studies on the nature of the T-antigen and the specific receptors for the lectin of Arachis hypogoea (ground-nut). Z Immunitatsforsch Allerg Klin Immunol 1969; 138: 423– 33. 49 Perret G, Bladier D, Gattegno L, Cornillot P. The role of T-agglutinin in the disappearance of erythrocytes artificially aged by desialylation. Mech Ageing Dev 1980; 12: 53– 63. 50 Jancik J, Schauer R. Sialic acid—a determinant of the life-time of rabbit erythrocytes. Hoppe Seylers Z Physiol Chem 1974; 355: 395– 400. 51 Durocher JR, Payne RC, Conrad ME. Role of sialic acid in erythrocyte survival. Blood 1975; 45: 11– 20. 52 Gattegno L, Bladier D, Cornillot P. The role of sialic acid in the determination of survival of rabbit erythrocytes in the circulation. Carbohydr Res 1974; 34: 361– 9. 53 Gattegno L, Bladier D, Garnier M, Cornillot P. Changes in carbohydrate content of surface membranes of human erythrocytes during ageing. Carbohydr Res 1976; 52: 197– 208. 54 Jancik J, Schauer R, Streicher HJ. Influence of membrane-bound N-acetylneuraminic acid on the survival of erythrocytes in man. Hoppe Seylers Z Physiol Chem 1975; 356: 1329– 31. 55 Eylar EH, Madoff MA, Brody OV, Oncley JL. The contribution of sialic acid to the surface charge of the erythrocyte. J Biol Chem 1962; 237: 1992– 2000. 56 Kay MM. Mechanism of removal of senescent cells by human macrophages in situ. Proc Natl Acad Sci U S A 1975; 72: 3521– 5. 57 Hübl W, Mostbeck B, Hartleb H, et al. Investigation of the pathogenesis of massive hemolysis in a case of Clostridium perfringens septicemia. Ann Hematol 1993; 67: 145– 7. 58 Davis HP, Treacy M, Parker D, Duggan G. Uncomplicated administration of blood products warmed to 37 degrees C in a patient with T activation of the red cell membrane. Clin Lab Haematol 1985; 7: 173– 6. 59 Seges RA, Kenny A, Bird GW, et al. Pediatric surgical patients with severe anaerobic infection: report of 16 T-antigen positive cases and possible hazards of blood transfusion. J Pediatr Surg 1981; 16: 905– 10. 60 Novak RW, Martin CR, Orsini EN. Hemolytic-uremic syndrome and T-cryptantigen exposure by neuraminidase-producing pneumococci: an emerging problem? Pediatr Pathol 1983; 1: 409– 13. 61 McGraw ME, Lendon M, Stevens RF, et al. Haemolytic uraemic syndrome and the Thomsen Friedenreich antigen. Pediatr Nephrol 1989; 3: 135– 9. 62 Squire R, Kiely E, Drake D, Lander A. Intravascular haemolysis in association with necrotising enterocolitis. J Pediatr Surg 1992; 27: 808– 10. 63 Eversole M, Nonemaker B, Zurek K, et al. Uneventful administration of plasma products in a recipient with T-activated red cells. Transfusion 1986; 26: 182– 5. 64 Heddle NM, Blajchman MA, Bodner N, Sacher R. Absence of hemolysis of T-activation red cells following infusion of blood products (abstract). Transfusion 1977; 17: 686. 65 Klein PJ, Bulla M, Newman RA, et al. Thomsen-Friedenreich antigen in haemolytic-uraemic syndrome. Lancet 1977; 2: 1024– 5. 66 Cabrera GR, Fortenberry JD, Warshaw BL, et al. Hemolytic uremic syndrome associated with invasive Streptococcus pneumoniae infection. Pediatrics 1998; 101: 699– 703. 67 Lenz G, Goes U, Baron D, et al. Association of exposed Thomsen-Friedenreich antigen (T antigen) and acute renal failure in septic patients. Lancet 1984; 1: 292– 3. 68 Hysell JK, Hysell JW, Nichols ME, et al. In vivo and in vitro activation of T-antigen receptors on leukocytes and platelets. Vox Sang 1976; 31(1 Suppl): 9– 15. 69 Havens PL, O'Rourke PP, Hahn J, et al. Laboratory and clinical variables to predict outcome in hemolytic-uremic syndrome. Am J Dis Child 1988; 142: 961– 4. 70 Rodwell R, Tudehope DI. Screening for cryptantigen exposure and polyagglutination in neonates with suspected necrotizing enterocolitis. J Paediatr Child Health 1993; 29: 16– 8. 71 Marshall LR, Barr AL, French NP, et al. A fatal case of necrotizing enterocolitis in a neonate with polyagglutination of red blood cells. J Paediatr Child Health 1993; 29: 63– 5. 72 Scott MD, Murad KL, Koumpouras F, et al. Chemical camouflage of antigenic determinants: stealth erythrocytes. Proc Natl Acad Sci U S A 1997; 94: 7566– 71. 73 Pineda AA, Zylstra VW, Clare DE, et al. Viability and functional integrity of washed platelets. Transfusion 1989; 29: 524– 7. 74 Allain JP. Non Factor VIII related constituents in concentrates. Scand J Haematol Suppl 1984; 41: 173– 80. 75 V Vengelen-Tyler, ed. Technical manual. 12th ed. Bethesda: American Association of Blood Banks, 1996. 76 Rodwell R, Lavercombe P, Taylor KM, et al. Diagnosis of cryptantigen exposure and polyagglutinability: management of transfusion therapy in a patient with sepsis and colitis. Anaesth Intensive Care 1995; 23: 208– 11. 77 Seger R, Joller P, Kenny A, et al. Potential hazards of blood-transfusion in Clostridia-associated necrotising enterocolitis. Lancet 1979; 1: 48– 9. 78 Bibbing J, Favara BE. Erythrocyte T activation. Rocky Mt Med J 1977; 74: 259– 61. 79 Levene NA, Levene C, Gekker K, et al. Th polyagglutination with fatal outcome in a patient with massive intravascular hemolysis and perforated tumor of colon. Am J Hematol 1990; 35: 127– 8. 80 Teach SJ, Priebe CJ, Guerina NG. Survival following congenital clostridial sepsis in a premature newborn. Clin Pediatr (Phila) 1994; 33: 746– 8. 81 Rickard KA, Robinson RJ, Worlledge SM. Acute acquired haemolytic anaemia associated with polyagglutination. Arch Dis Child 1969; 44: 102– 5. 82 Jorgensen JR. Prenatal T-transformation? A case of polyagglutinable cord blood erythrocytes. Vox Sang 1967; 13: 225– 32. 83 Gray JM, Beck ML, Oberman HA. Clostridial-induced type I polyagglutinability with associated intravascular hemolysis. Vox Sang 1972; 22: 379– 83. 84 Bird T, Stephenson J. Acute haemolytic anaemia associated with polyagglutinability of red cells. J Clin Pathol 1973; 26: 868– 70. 85 Obeid D, Bird GW, Wingham J. Prolonged erythrocyte T-polyagglutination in two children with bowel disorders. J Clin Pathol 1977; 30: 953– 5. 86 Perkash A, Carlson A, Ellisor S. Polyagglutination due to combined T and Tk activation. Transfusion 1980; 20: 301– 5. 87 Seger R, Joller P, Baerlocher K, et al. Hemolytic-uremic syndrome associated with neuraminidase-producing microorganisms: treatment by exchange transfusion. Helv Paediatr Acta 1980; 35: 359– 67. 88 Mullard GW, Thompson IH, Lee D, Owen WG. Strong T-transformation associated with a severe haemolytic reaction in a young infant transfused with packed red cells. Clin Lab Haematol 1981; 3: 357– 64. 89 Klarkowski DB, Ford DS. A case of polyagglutination with features of Th and Tk activation associated with an acquired B antigen. Transfusion 1983; 23: 59– 61. 90 Placzek MM, Gorst DW. T activation haemolysis and death after blood transfusion. Arch Dis Child 1987; 62: 743– 4. 91 Sayas MJ, Pastor E, Casanova C, et al. Severe intravascular haemolysis associated with polyagglutinability. Br J Haematol 1990; 75: 433– 4. Citing Literature Volume40, Issue7July 2000Pages 801-812 ReferencesRelatedInformation