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Development of a sensor based on tetracyanoethylenide (LiTCNE)/poly-l-lysine (PLL) for dopamine determination

2004; Elsevier BV; Volume: 50; Issue: 13 Linguagem: Inglês

10.1016/j.electacta.2004.11.012

1873-3859

Rita de Cássia Silva Luz, Flávio Santos Damos, Adriano Bof de Oliveira, Johannes Beck, Lauro T. Kubota,

Electrochemical Analysis and Applications

The catalytic oxidation of dopamine (DA) at a LiTCNE (lithium tetracyanoethylenide) film modified electrode is studied by electrochemical approaches. The immobilization of LiTCNE was performed by a polymer (poly-l-lysine) to prepare this modified electrode and its application for dopamine (DA) determination is described in detail. The modified electrode showed a high activity for the electrooxidation of dopamine (DA) at Ep = 0.20 V versus SCE. The modified electrode presented a wide linear response range for DA from 0.01 up to 10 μmol l−1 by differential pulse voltammetry (DPV) with a detection limit of 0.5 nmol l−1. The repeatability of the proposed sensor evaluated in term of relative standard deviation was 3.2% for n = 10. The sensor was applied for the determination of dopamine in pharmaceutical formulations and the average recovery for these samples was 101.9 (±0.1)%.