Produção Nacional
Revisado por pares
Resveratrol reduces vacuous chewing movements induced by acute treatment with fluphenazine
2012; Elsevier BV; Volume: 101; Issue: 2 Linguagem: Inglês
10.1016/j.pbb.2012.01.007
ISSN1873-5177
AutoresAlcindo Busanello, Luis Ricardo Peroza, Caroline Wagner, Jéssie Haigert Sudati, Romaiana Picada Pereira, Alessandro de Souza Prestes, João Batista Teixeira da Rocha, Roselei Fachinetto, Nilda Vargas Barbosa,
Tópico(s)Sirtuins and Resveratrol in Medicine
ResumoTreatment with classical neuroleptics in humans can produce a serious side effect, known as tardive dyskinesia (TD). Here, we examined the possible neuroprotective effects of resveratrol, a polyphenol compound contained in red grapes and red wine, in an animal model of orofacial dyskinesia (OD) induced by acute treatment with fluphenazine. Adult male rats were treated during 3 weeks with fluphenazine enantate (25 mg/kg, i.m., single administration) and/or resveratrol (1 mg/kg, s.c., 3 times a week). Vacuous chewing movements (VCMs), locomotor and exploratory performance were evaluated. Fluphenazine treatment produced VCM in 70% of rats and the concomitant treatment with resveratrol decreased the prevalence to 30%, but did not modify the intensity of VCMs. Furthermore, the fluphenazine administration reduced the locomotor and exploratory activity of animals in the open field test. Resveratrol co-treatment was able to protect the reduction of both parameters. Taken together, our data suggest that resveratrol could be considered a potential neuroprotective agent by reducing motor disorders induced by fluphenazine treatment.
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