The mechanism of action of glatiramer acetate treatment in multiple sclerosis
2009; Lippincott Williams & Wilkins; Volume: 74; Issue: 1_supplement_1 Linguagem: Inglês
10.1212/wnl.0b013e3181c97e39
ISSN1526-632X
AutoresMichael K. Racke, Amy E. Lovett‐Racke, Nitin J. Karandikar,
Tópico(s)Peripheral Neuropathies and Disorders
ResumoGlatiramer acetate (formerly known as copolymer 1) is the major noninterferon immunomodulatory agent used in the treatment of relapsing-remitting multiple sclerosis. Its mechanism of action over the past 40 years has evolved with our understanding of the immune response.We review the various mechanisms that have been proposed for this random polymer over the years, with emphasis on recent methods that utilize modern immunologic techniques.Studies describing processes such as immune deviation and effects on regulatory T cells and antigen-presenting cells are presented.Effects of glatiramer acetate on the immune response have evolved as our technical abilities and knowledge of the immune response itself have developed.
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