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The Interactions of α -Thalassemia with Hemoglobinopathies

1991; Elsevier BV; Volume: 5; Issue: 3 Linguagem: Inglês

10.1016/s0889-8588(18)30425-8

1558-1977

Martin H. Steinberg,

Blood groups and transfusion

Because of their high prevalence throughout the world, alpha-thalassemia and hemoglobinopathies often occur in the same individual. Southern blot hybridization analysis of the alpha-globin gene cluster permits the detection of the common deletion alpha-thalassemias and the definition of the phenotypes affiliated with the interactions of alpha-thalassemia and hemoglobinopathies. Important insights into the pathophysiology of Hb SS have been gained, and the nature of the perturbation of heterozygous hemoglobinopathies by alpha-thalassemia has been established.