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Asymmetric Synthesis of 3,4-Dihydrocoumarins by Rhodium-Catalyzed Reaction of 3-(2-Hydroxyphenyl)cyclobutanones

2007; American Chemical Society; Volume: 129; Issue: 40 Linguagem: Inglês

10.1021/ja075141g

1943-2984

Takanori Matsuda, Masanori Shigeno, Masahiro Murakami,

Asymmetric Hydrogenation and Catalysis

3,4-Dihydrocoumarin derivatives were synthesized in a highly enantioselective manner from 3-(2-hydroxyphenyl)cyclobutanones through enantioselective carbon−carbon bond cleavage. A cascade reaction with electron-deficient alkenes introduced a carbon−carbon bond at the 5-position of the dihydrocoumarins.