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Membranous proliferation of lens epithelial cells on acrylic, silicone, and poly(methyl methacrylate) lenses

2001; Lippincott Williams & Wilkins; Volume: 27; Issue: 10 Linguagem: Inglês

10.1016/s0886-3350(01)00870-7

1873-4502

Daijiro Kurosaka, Katsuhiko Kato,

Anorectal Disease Treatments and Outcomes

Purpose: To determine whether intraocular lens (IOL) material influences the membranous proliferation of lens epithelial cells (LECs) on the anterior surface of the IOL. Setting: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan. Methods: This prospective study included 87 eyes of 87 consecutive patients who had cataract surgery with IOL implantation. Patients were randomly assigned to receive a single-piece poly(methyl methacrylate) (PMMA) IOL, a 3-piece silicone IOL, or a 3-piece acrylic IOL. Postoperatively, the IOL optic was examined by slitlamp microscopy at 1 and 10 days and 1, 2, and 3 months to determine the incidence, duration, and extent of membranous LEC proliferation. The optic was also examined at 6, 9, and 12 months if proliferation persisted. Results: Thirteen eyes were excluded from analysis because of incomplete coverage of the IOL rim by the anterior capsule margin; 74 remaining eyes were studied. All patients obtained good postoperative visual acuity (20/25 or better). Incidence (P = .0024) and duration (P = .0002) of membranous LEC proliferation with the acrylic IOL was greater than with the other 2 types. Proliferation on the acrylic IOL was more extensive than on the PMMA IOL 10 days postoperatively (P < .05) and on the silicone IOL at 10 days (P < .01) and 1 month (P < .01). However, LEC proliferation on the 3 types of IOLs usually decreased by the third postoperative month, and proliferation did not disturb visual acuity. Conclusions: The material of an IOL influenced membranous proliferation of LECs on its anterior surface. Proliferation on the acrylic IOL persisted longer than on the other 2 types but did not cause visual symptoms.